› 6rp8

X-ray diffraction
2.6Å resolution

Crystal Structure of Ipilimumab Fab complexed with CTLA-4 at 2.6A resolution

Released:
DOI: 10.2210/pdb6rp8/pdb
PDB entry 6rp8 coloured by chain, front view.
PDB entry 6rp8 coloured by chain, side view.
PDB entry 6rp8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhang F, Zhou A

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210685 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antibody Ipilimumab heavy chain Chains: H, h
Molecule details ›
Chains: H, h
Length: 225 amino acids
Theoretical weight: 24.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Antibody Ipilimumab light chain Chains: L, l
Molecule details ›
Chains: L, l
Length: 215 amino acids
Theoretical weight: 23.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Cytotoxic T-lymphocyte protein 4 Chains: C, c
Molecule details ›
Chains: C, c
Length: 118 amino acids
Theoretical weight: 12.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16410 (Residues: 37-154; Coverage: 63%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 56.91Å b: 129.89Å c: 76.91Å
α: 90° β: 96.44° γ: 90°
R-values:
R R work R free
0.214 0.211 0.267
Expression system: Homo sapiens

Quick links