› 6rpj

X-ray diffraction
3.25Å resolution

A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4

Released:
DOI: 10.2210/pdb6rpj/pdb
PDB entry 6rpj coloured by chain, front view.
PDB entry 6rpj coloured by chain, side view.
PDB entry 6rpj coloured by chain, top view.
Source organisms:
Entry authors: Gao H, Zhou A, Zhang F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210692 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Cytotoxic T-lymphocyte protein 4 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 129 amino acids
Theoretical weight: 13.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16410 (Residues: 37-156; Coverage: 64%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain
A non-blocking CTLA-4 nanobody Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 142 amino acids
Theoretical weight: 15.2 KDa
Source organism: Camelus bactrianus
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 4 x NAG
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: C2
Unit cell:
a: 309.977Å b: 75.708Å c: 83.047Å
α: 90° β: 100.05° γ: 90°
R-values:
R R work R free
0.25 0.249 0.262
Expression system: Homo sapiens

Quick links