› 6s3q

Electron Microscopy
3.34Å resolution

Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with TFB-TBOA

Released:
DOI: 10.2210/pdb6s3q/pdb
PDB entry 6s3q coloured by chain, front view.
PDB entry 6s3q coloured by chain, side view.
PDB entry 6s3q coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Baronina A, Pike ACW, Yu X, Dong YY, Shintre CA, Tessitore A, Chu A, Rotty B, Venkaya S, Mukhopadhyay S, Borkowska O, Chalk R, Shrestha L, Burgess-Brown NA, Edwards AM, Arrowsmith CH, Bountra C, Han S, Carpenter EP, Structural Genomics Consortium (SGC)
Related structures: EMD-10094

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154932 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Excitatory amino acid transporter 3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 487 amino acids
Theoretical weight: 53.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43005 (Residues: 1-480; Coverage: 92%)
Gene names: EAAC1, EAAT3, HEAAC1, SLC1A1
Sequence domains: Sodium:dicarboxylate symporter family

Ligands and Environments

3 bound ligands:
Ligand 7O9 3 x 7O9
Ligand Y01 3 x Y01
Ligand PC1 15 x PC1
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.34Å
Relevant EMDB volumes: EMD-10094
Expression system: Spodoptera frugiperda

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