› 6s7p

Electron Microscopy
3.2Å resolution

Nucleotide bound ABCB4

Released:
DOI: 10.2210/pdb6s7p/pdb
PDB entry 6s7p coloured by chain, front view.
PDB entry 6s7p coloured by chain, side view.
PDB entry 6s7p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human lipid exporter ABCB4 in a lipid environment.
Olsen JA, Alam A, Kowal J, Stieger B, Locher KP
Nat Struct Mol Biol 27 62-70 (2020)
PMID: 31873305
Related structures: EMD-10111

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149238 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylcholine translocator ABCB4 Chain: A
Molecule details ›
Chain: A
Length: 1279 amino acids
Theoretical weight: 140.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P21439 (Residues: 1-1286; Coverage: 100%)
Gene names: ABCB4, MDR3, PGY3
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ATP 2 x ATP
Ligand MG 1 x MG
Ligand CLR 8 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-10111
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Large nanodiscs going viral.
Nasr ML. (2020)
4 more

12 mentions without citation

Structural and functional diversity calls for a new classification of ABC transporters.
Thomas et al. (2020)
11 more