› 6ssk

Electron Microscopy
3.18Å resolution

Human endogenous retrovirus (HML2) mature capsid assembly, D5 capsule

Released:
DOI: 10.2210/pdb6ssk/pdb
PDB entry 6ssk coloured by chain, front view.
PDB entry 6ssk coloured by chain, side view.
PDB entry 6ssk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for Fullerene geometry in a human endogenous retrovirus capsid.
Acton O, Grant T, Nicastro G, Ball NJ, Goldstone DC, Robertson LE, Sader K, Nans A, Ramos A, Stoye JP, Taylor IA, Rosenthal PB
Nat Commun 10 5822 (2019)
PMID: 31862888
Related structures: EMD-10296

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 90-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158999 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endogenous retrovirus group K member 24 Gag polyprotein Chains: A, B, C, D, E, F, G, H, I
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I
Length: 248 amino acids
Theoretical weight: 27.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63145 (Residues: 283-528; Coverage: 37%)
Gene name: ERVK-24
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.18Å
Relevant EMDB volumes: EMD-10296
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Viral vector-based gene therapies in the clinic.
Zhao et al. (2022)
1 more