› 6sws

X-ray diffraction
3Å resolution

The DBB dimerization domain of B-cell adaptor for PI3K (BCAP) is required for down regulation of inflammatory signalling through the Toll-like receptor pathway

Released:
DOI: 10.2210/pdb6sws/pdb
PDB entry 6sws coloured by chain, front view.
PDB entry 6sws coloured by chain, side view.
PDB entry 6sws coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain.
Lauenstein JU, Scherm MJ, Udgata A, Moncrieffe MC, Fisher DI, Gay NJ
J Immunol 204 2269-2276 (2020)
PMID: 32198144

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoinositide 3-kinase adapter protein 1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 113 amino acids
Theoretical weight: 12.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ZUJ8 (Residues: 179-288; Coverage: 14%)
Gene names: BCAP, PIK3AP1
Sequence domains: Dof, BCAP, and BANK (DBB) motif,

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P4322
Unit cell:
a: 87.169Å b: 87.169Å c: 234.075Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.194 0.238
Expression system: Escherichia coli

Quick links

Citations

1 review citation

TIRAP in the Mechanism of Inflammation.
Rajpoot et al. (2021)
2 other articles

1 mention without citation

Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain.
Lauenstein et al. (2020)