› 6t3j

X-ray diffraction
3.05Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208029 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
IgG1-hDR5-01-Heavy Chain Chains: A, F
Molecule details ›
Chains: A, F
Length: 232 amino acids
Theoretical weight: 25.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
IgG1-hDR5-01-Light Chain Chains: B, G
Molecule details ›
Chains: B, G
Length: 214 amino acids
Theoretical weight: 23.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
IgG1-hDR5-05-Heavy Chain Chains: C, H
Molecule details ›
Chains: C, H
Length: 232 amino acids
Theoretical weight: 25.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
IgG1-hDR5-05-Light Chain Chains: D, I
Molecule details ›
Chains: D, I
Length: 213 amino acids
Theoretical weight: 23.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Tumor necrosis factor receptor superfamily member 10B Chains: E, J
Molecule details ›
Chains: E, J
Length: 131 amino acids
Theoretical weight: 14.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14763 (Residues: 58-184; Coverage: 33%)
Gene names: DR5, KILLER, TNFRSF10B, TRAILR2, TRICK2, UNQ160/PRO186, ZTNFR9
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 121.604Å b: 90.926Å c: 138.379Å
α: 90° β: 103.79° γ: 90°
R-values:
R R work R free
0.251 0.25 0.282
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Fc-Engineered Antibodies with Enhanced Fc-Effector Function for the Treatment of B-Cell Malignancies.
van der Horst et al. (2020)
7 more