› 6t7v

X-ray diffraction
2.6Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171935 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kelch-like ECH-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14145 (Residues: 321-609; Coverage: 46%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: Kelch motif
Nuclear factor erythroid 2-related factor 2 Chain: I
Molecule details ›
Chain: I
Length: 9 amino acids
Theoretical weight: 1.02 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16236 (Residues: 76-84; Coverage: 2%)
Gene names: NFE2L2, NRF2

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 75.43Å b: 75.43Å c: 114.497Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.202 0.275
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

Nrf2/Keap1/ARE signaling: Towards specific regulation.
Ulasov et al. (2022)
2 more

1 mention without citation

KEAP1-NRF2 protein-protein interaction inhibitors: Design, pharmacological properties and therapeutic potential.
Crisman et al. (2023)