› 6tu9

X-ray diffraction
1.94Å resolution

The ROR1 Pseudokinase Domain Bound To Ponatinib

Released:
DOI: 10.2210/pdb6tu9/pdb
PDB entry 6tu9 coloured by chain, front view.
PDB entry 6tu9 coloured by chain, side view.
PDB entry 6tu9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Sheetz JB, Mathea S, Karvonen H, Malhotra K, Chatterjee D, Niininen W, Perttilä R, Preuss F, Suresh K, Stayrook SE, Tsutsui Y, Radhakrishnan R, Ungureanu D, Knapp S, Lemmon MA
Mol Cell 79 390-405.e7 (2020)
PMID: 32619402

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169649 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inactive tyrosine-protein kinase transmembrane receptor ROR1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 35.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q01973 (Residues: 453-752; Coverage: 33%)
Gene names: NTRKR1, ROR1
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand 0LI 2 x 0LI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 54.29Å b: 85.969Å c: 72.98Å
α: 90° β: 91.045° γ: 90°
R-values:
R R work R free
0.21 0.209 0.241
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention.
Menck et al. (2021)
4 more

4 mentions without citation

Looking lively: emerging principles of pseudokinase signaling.
Sheetz et al. (2022)
3 more