› 6tub

Solid-state NMR

Beta-endorphin amyloid fibril

Released:
DOI: 10.2210/pdb6tub/pdb
PDB entry 6tub coloured by chain, ensemble of 10 models, front view.
PDB entry 6tub coloured by chain, ensemble of 10 models, side view.
PDB entry 6tub coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The three-dimensional structure of human β-endorphin amyloid fibrils.
Seuring C, Verasdonck J, Gath J, Ghosh D, Nespovitaya N, Wälti MA, Maji SK, Cadalbert R, Güntert P, Meier BH, Riek R
Nat Struct Mol Biol 27 1178-1184 (2020)
PMID: 33046908

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134103 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-endorphin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 31 amino acids
Theoretical weight: 3.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01189 (Residues: 237-267; Coverage: 13%)
Gene name: POMC
Sequence domains: Opioids neuropeptide

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 9%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

9 review citations

The expanding amyloid family: Structure, stability, function, and pathogenesis.
Sawaya et al. (2021)
8 more

2 mentions without citation

Protein Amyloid Cofactors: Charged Side-Chain Arrays Meet Their Match?
Lewkowicz et al. (2021)
1 more