› 6tx2

X-ray diffraction
2.09Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192667 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone PARylation factor 1 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 36.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NWY4 (Residues: 37-346; Coverage: 90%)
Gene names: C4orf27, HPF1
Sequence domains: Histone PARylation factor 1

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P65
Unit cell:
a: 115.099Å b: 115.099Å c: 90.388Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.188 0.207
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

42 review citations

NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential.
Xie et al. (2020)
41 more

1 mention without citation

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Suskiewicz et al. (2020)