› 6txs

X-ray diffraction
2.2Å resolution

The structure of the FERM domain and helical linker of human moesin bound to a CD44 peptide

Released:
DOI: 10.2210/pdb6txs/pdb
PDB entry 6txs coloured by chain, front view.
PDB entry 6txs coloured by chain, side view.
PDB entry 6txs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
Du Y, Bradshaw WJ, Leisner TM, Annor-Gyamfi JK, Qian K, Bashore FM, Sikdar A, Nwogbo FO, Ivanov AA, Frye SV, Gileadi O, Brennan PE, Levey AI, Axtman AD, Pearce KH, Fu H, Katis VL
J Biol Chem 105382 (2023)
PMID: 37866628

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147593 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Moesin Chain: AAA
Molecule details ›
Chain: AAA
Length: 347 amino acids
Theoretical weight: 41.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26038 (Residues: 1-346; Coverage: 60%)
Gene name: MSN
Sequence domains:
CD44 antigen Chain: BBB
Molecule details ›
Chain: BBB
Length: 8 amino acids
Theoretical weight: 973 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P16070 (Residues: 678-685; Coverage: 1%)
Gene names: CD44, LHR, MDU2, MDU3, MIC4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: I41
Unit cell:
a: 119.967Å b: 119.967Å c: 64.596Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.276
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

1 review citation

Fused Tetrahydroquinolines Are Interfering with Your Assay.
Bashore et al. (2023)