6u1n

Electron Microscopy
4Å resolution

GPCR-Beta arrestin structure in lipid bilayer

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-139956 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Muscarinic acetylcholine receptor M2; Vasopressin V2 receptor Chain: R
Molecule details ›
Chain: R
Length: 509 amino acids
Theoretical weight: 56.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08172 (Residues: 2-466; Coverage: 100%)
  • Canonical: P30518 (Residues: 343-371; Coverage: 8%)
Gene names: ADHR, AVPR2, CHRM2, DIR, DIR3, V2R
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Beta-arrestin-1 Chain: C
Molecule details ›
Chain: C
Length: 401 amino acids
Theoretical weight: 45.02 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P29066 (Residues: 2-393; Coverage: 94%)
Gene name: Arrb1
Sequence domains:
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 237 amino acids
Theoretical weight: 25.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: V9HW68 (Residues: 20-247; Coverage: 50%)
Gene name: HEL-214
Sequence domains:
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z3Y4 (Residues: 23-236; Coverage: 100%)
Sequence domains:

Ligands and Environments

1 bound ligand:
2 modified residues:

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-20612
Expression systems:
  • Homo sapiens
  • Escherichia coli