6u2f

X-ray diffraction
2.94Å resolution

PCSK9-Fab 7G7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)IGLLR - NH2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-102767 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 700 amino acids
Theoretical weight: 75.51 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q8NBP7 (Residues: 1-692; Coverage: 100%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains:
Organo-peptide PCSK9 inhibitor Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.49 KDa
Source organism: synthetic construct
Expression system: Not provided
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 24.12 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UniProt:
  • Canonical: Q569X1 (Residues: 20-116, 117-239; Coverage: 48%)
Gene name: Ighg
Sequence domains:
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.66 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UniProt:
  • Canonical: A0A0U5BC76 (Residues: 21-234; Coverage: 100%)
Gene name: LC
Sequence domains:

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I222
Unit cell:
a: 110.569Å b: 142.74Å c: 239.287Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.174 0.209
Expression systems:
  • Cricetulus griseus
  • Not provided
  • Mus musculus