› 6u36

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212628 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 707 amino acids
Theoretical weight: 76.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NBP7 (Residues: 31-692; Coverage: 100%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains:
Fab Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 246 amino acids
Theoretical weight: 26.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Fab Light Chain Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand PVM 1 x PVM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P65
Unit cell:
a: 155.605Å b: 155.605Å c: 152.451Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.24 0.251
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

4 review citations

The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents.
Coll-Martínez et al. (2020)
3 more

2 mentions without citation

PCSK9 as a Target for Development of a New Generation of Hypolipidemic Drugs.
Kuzmich et al. (2022)
1 more