› 6u3m

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-127610 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class II histocompatibility antigen, DQ alpha 1 chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 191 amino acids
Theoretical weight: 21.5 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01909 (Residues: 24-206; Coverage: 79%)
Gene name: HLA-DQA1
Sequence domains:
Ig-like domain-containing protein Chains: B, D
Molecule details ›
Chains: B, D
Length: 206 amino acids
Theoretical weight: 23.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O19712 (Residues: 1-192; Coverage: 84%)
Gene name: HLA-DQB1
Sequence domains:
Alpha1a peptide Chains: E, F
Molecule details ›
Chains: E, F
Length: 21 amino acids
Theoretical weight: 2.17 KDa
Source organism: Pseudomonas fluorescens
Expression system: Trichoplusia ni

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand GOL 4 x GOL
Ligand PO4 1 x PO4
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 94.935Å b: 96.276Å c: 105.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.19 0.22
Expression system: Trichoplusia ni

Quick links

Citations

22 review citations

The microbiome and human cancer.
Sepich-Poore et al. (2021)
21 more

1 mention without citation

Structural Perspective of Gliadin Peptides Active in Celiac Disease.
Falcigno et al. (2020)