› 6u4k

X-ray diffraction
2.56Å resolution

Human talin2 residues 1-403

Released:
DOI: 10.2210/pdb6u4k/pdb
PDB entry 6u4k coloured by chain, front view.
PDB entry 6u4k coloured by chain, side view.
PDB entry 6u4k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A distinct talin2 structure directs isoform specificity in cell adhesion.
Rangarajan ES, Primi MC, Colgan LA, Chinthalapudi K, Yasuda R, Izard T
J Biol Chem 295 12885-12899 (2020)
PMID: 32605925

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Talin-2 Chain: A
Molecule details ›
Chain: A
Length: 405 amino acids
Theoretical weight: 46.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y4G6 (Residues: 1-403; Coverage: 16%)
Gene names: KIAA0320, TLN2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P65
Unit cell:
a: 58.885Å b: 58.885Å c: 203.799Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.192 0.247
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

Initiation of focal adhesion assembly by talin and kindlin: A dynamic view.
Zhu et al. (2021)
4 other articles

4 mentions without citation

Structural Basis of β2 Integrin Inside-Out Activation.
Wen et al. (2022)
3 more