› 6u6v

X-ray diffraction
1.9Å resolution

Crystal structure of human PD-1H / VISTA

Released:
DOI: 10.2210/pdb6u6v/pdb
PDB entry 6u6v coloured by chain, front view.
PDB entry 6u6v coloured by chain, side view.
PDB entry 6u6v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into T cell coinhibition by PD-1H (VISTA).
Slater BT, Han X, Chen L, Xiong Y
Proc. Natl. Acad. Sci. U.S.A. (2020)
PMID: 31919279

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190664 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
V-type immunoglobulin domain-containing suppressor of T-cell activation Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 19.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H7M9 (Residues: 33-193; Coverage: 58%)
Gene names: C10orf54, PP2135, SISP1, UNQ730/PRO1412, VISTA, VSIR
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 28.821Å b: 55.833Å c: 42.271Å
α: 90° β: 97.69° γ: 90°
R-values:
R R work R free
0.21 0.207 0.25
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Revisiting Immunotherapy: A Focus on Prostate Cancer.
Cha et al. (2020)
9 more

2 mentions without citation

VISTA: A Mediator of Quiescence and a Promising Target in Cancer Immunotherapy.
Yuan et al. (2021)
1 more