› 6u7m

Electron Microscopy
3.8Å resolution

Cryo-EM Structure of Helical Lipoprotein Lipase

Released:
DOI: 10.2210/pdb6u7m/pdb
PDB entry 6u7m coloured by chain, front view.
PDB entry 6u7m coloured by chain, side view.
PDB entry 6u7m coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage.
Gunn KH, Roberts BS, Wang F, Strauss JD, Borgnia MJ, Egelman EH, Neher SB
Proc Natl Acad Sci U S A 117 10254-10264 (2020)
PMID: 32332168
Related structures: EMD-20673

Function and Biology Details

Reactions catalysed: 
Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 30-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145684 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lipoprotein lipase Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, a, b, c, d, e, f, g, h, i
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, a, b, c, d, e, f, g, h, i
Length: 478 amino acids
Theoretical weight: 53.45 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P11151 (Residues: 1-478; Coverage: 100%)
Gene name: LPL
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-20673

Quick links

Citations

2 review citations

Lipoprotein Lipase and Its Regulators: An Unfolding Story.
Wu et al. (2021)
1 more

4 mentions without citation

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity.
Kristensen et al. (2021)
3 more