6ue9

Electron Microscopy
2.9Å resolution

Structure of tetrameric sIgA complex (Class 2)

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the secretory immunoglobulin A core.
Science 367 1008-1014 (2020)
PMID: 32029686
Related structures: EMD-20751

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-134435 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Immunoglobulin heavy constant alpha 2 Chains: A, B, E, F, G, H, K, L
Molecule details ›
Chains: A, B, E, F, G, H, K, L
Length: 245 amino acids
Theoretical weight: 26.68 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01877 (Residues: 110-321; Coverage: 54%)
Gene name: IGHA2
Sequence domains:
Secretory component Chain: C
Molecule details ›
Chain: C
Length: 591 amino acids
Theoretical weight: 65.15 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01833 (Residues: 19-603; Coverage: 78%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain
Immunoglobulin J chain Chain: D
Molecule details ›
Chain: D
Length: 137 amino acids
Theoretical weight: 15.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01591 (Residues: 23-159; Coverage: 100%)
Gene names: IGCJ, IGJ, JCHAIN
Sequence domains: Immunoglobulin J chain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-20751
Expression system: Cricetulus griseus