6ujb

Electron Microscopy
3.51Å resolution

Integrin alpha-v beta-8 in complex with the Fabs C6D4 and 11D12v2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-209294 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (6 distinct):
Integrin alpha-V Chain: A
Molecule details ›
Chain: A
Length: 1018 amino acids
Theoretical weight: 112.81 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06756 (Residues: 31-1048; Coverage: 100%)
Gene names: ITGAV, MSK8, VNRA, VTNR
Sequence domains:
Integrin beta-8 Chain: B
Molecule details ›
Chain: B
Length: 727 amino acids
Theoretical weight: 81.28 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P26012 (Residues: 43-769; Coverage: 100%)
Gene name: ITGB8
Sequence domains:
C6D4 heavy chain Fab Chain: E
Molecule details ›
Chain: E
Length: 212 amino acids
Theoretical weight: 22.79 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
C6D4 light chain Fab Chain: F
Molecule details ›
Chain: F
Length: 219 amino acids
Theoretical weight: 24.14 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.51Å
Relevant EMDB volumes: EMD-20795
Expression systems:
  • Cricetulus griseus
  • Homo sapiens