› 6upv

Electron Microscopy
3.2Å resolution

Alpha-E-catenin ABD-F-actin complex

Released:
DOI: 10.2210/pdb6upv/pdb
PDB entry 6upv coloured by chain, front view.
PDB entry 6upv coloured by chain, side view.
PDB entry 6upv coloured by chain, top view.
Source organisms:
Primary publication:
Molecular mechanism for direct actin force-sensing by α-catenin.
Mei L, Espinosa de Los Reyes S, Reynolds MJ, Leicher R, Liu S, Alushin GM
Elife 9 (2020)
PMID: 32969337
Related structures: EMD-20843

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152829 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Catenin alpha-1 Chains: L, M
Molecule details ›
Chains: L, M
Length: 906 amino acids
Theoretical weight: 100.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35221 (Residues: 1-906; Coverage: 100%)
Gene name: CTNNA1
Sequence domains: Vinculin family
Actin, alpha skeletal muscle Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 375 amino acids
Theoretical weight: 41.88 KDa
Source organism: Gallus gallus
UniProt:
  • Canonical: P68139 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin

Ligands and Environments

2 bound ligands:
Ligand ADP 5 x ADP
Ligand MG 5 x MG
1 modified residue:
Ligand HIC 5 x HIC

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-20843
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Effects of forces on chromatin.
Amar et al. (2021)
8 more

8 mentions without citation

Molecular mechanism for direct actin force-sensing by α-catenin.
Mei et al. (2020)
7 more