› 6ut2

Solution NMR

3D structure of the leiomodin/tropomyosin binding interface

Released:
DOI: 10.2210/pdb6ut2/pdb
PDB entry 6ut2 coloured by chain, ensemble of 10 models, front view.
PDB entry 6ut2 coloured by chain, ensemble of 10 models, side view.
PDB entry 6ut2 coloured by chain, ensemble of 10 models, top view.
Source organisms:
Primary publication:
Leiomodin creates a leaky cap at the pointed end of actin-thin filaments.
Tolkatchev D, Smith GE, Schultz LE, Colpan M, Helms GL, Cort JR, Gregorio CC, Kostyukova AS
PLoS Biol 18 e3000848 (2020)
PMID: 32898131

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136508 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Leiomodin-2 Chain: A
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6P5Q4 (Residues: 2-41; Coverage: 7%)
Gene name: LMOD2
General control transcription factor GCN4; Tropomyosin alpha-1 chain Chains: B, C
Molecule details ›
Chains: B, C
Length: 33 amino acids
Theoretical weight: 3.91 KDa
Source organisms: Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09493 (Residues: 1-14; Coverage: 5%)
  • Canonical: P03069 (Residues: 264-281; Coverage: 6%)
Gene names: AAS101, AAS3, ARG9, C15orf13, GCN4, TMSA, TPM1, YEL009C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 41%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The Mechanisms of Thin Filament Assembly and Length Regulation in Muscles.
Szikora et al. (2022)
9 other articles

3 mentions without citation

The role of leiomodin in actin dynamics: a new road or a secret gate.
Tolkatchev et al. (2022)
2 more