6v00

Electron Microscopy
3.1Å resolution

structure of human KCNQ1-KCNE3-CaM complex

Released:
Primary publication:
Structural Basis of Human KCNQ1 Modulation and Gating.
Cell 180 340-347.e9 (2020)
PMID: 31883792
Related structures: EMD-20966

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-143984 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Potassium voltage-gated channel subfamily KQT member 1 Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 557 amino acids
Theoretical weight: 63.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P51787 (Residues: 76-620; Coverage: 81%)
Gene names: KCNA8, KCNA9, KCNQ1, KVLQT1
Sequence domains:
Calmodulin-1 Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair
MCherry fluorescent protein; Potassium voltage-gated channel subfamily E member 3 Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 355 amino acids
Theoretical weight: 40.1 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: X5DSL3 (Residues: 1-236; Coverage: 100%)
  • Canonical: Q9Y6H6 (Residues: 1-103; Coverage: 100%)
Gene names: KCNE3, mCherry
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-20966
Expression system: Homo sapiens