› 6v1d

X-ray diffraction
2.4Å resolution

Crystal structure of human trefoil factor 1

Released:
DOI: 10.2210/pdb6v1d/pdb
PDB entry 6v1d coloured by chain, front view.
PDB entry 6v1d coloured by chain, side view.
PDB entry 6v1d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Trefoil factors share a lectin activity that defines their role in mucus.
Järvå MA, Lingford JP, John A, Soler NM, Scott NE, Goddard-Borger ED
Nat Commun 11 2265 (2020)
PMID: 32404934

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137453 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trefoil factor 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 51 amino acids
Theoretical weight: 5.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04155 (Residues: 27-74; Coverage: 80%)
Gene names: BCEI, PS2, TFF1
Sequence domains: Trefoil (P-type) domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 3 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 44.928Å b: 41.905Å c: 45.831Å
α: 90° β: 115.57° γ: 90°
R-values:
R R work R free
0.196 0.194 0.226
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Carbohydrate-active enzymes (CAZymes) in the gut microbiome.
Wardman et al. (2022)
6 more

1 mention without citation

Trefoil factors share a lectin activity that defines their role in mucus.
Järvå et al. (2020)