› 6v9v

Electron Microscopy
2.6Å resolution

Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG

Released:
DOI: 10.2210/pdb6v9v/pdb
PDB entry 6v9v coloured by chain, front view.
PDB entry 6v9v coloured by chain, side view.
PDB entry 6v9v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D
Nature 585 141-145 (2020)
PMID: 32641835
Related structures: EMD-21127

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily A member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1119 amino acids
Theoretical weight: 127.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75762 (Residues: 1-1119; Coverage: 100%)
Gene names: ANKTM1, TRPA1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand QT4 4 x QT4
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.6Å
Relevant EMDB volumes: EMD-21127
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Oxidative eustress: On constant alert for redox homeostasis.
Sies H. (2021)
8 more

11 mentions without citation

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
10 more