6vae

Electron Microscopy
3.5Å resolution

Mono-ubiquitinated Fanconi Anemia ID complex bound to ICL DNA

Released:
Source organism: Homo sapiens
Related structures: EMD-21138

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-120750 (preferred)
Entry contents:
3 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (5 distinct):
Fanconi anemia group I protein Chain: A
Molecule details ›
Chain: A
Length: 1328 amino acids
Theoretical weight: 149.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NVI1 (Residues: 1-1328; Coverage: 100%)
Gene names: FANCI, KIAA1794
Sequence domains:
Fanconi anemia group D2 protein Chain: B
Molecule details ›
Chain: B
Length: 1451 amino acids
Theoretical weight: 164.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BXW9 (Residues: 1-1451; Coverage: 100%)
Gene names: FACD, FANCD2
Sequence domains: Fanconi anaemia protein FancD2 nuclease
Ubiquitin Chains: C, D
Molecule details ›
Chains: C, D
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CG48 (Residues: 609-684; Coverage: 11%)
Gene name: UBC
Sequence domains: Ubiquitin family
DNA (29-MER) Chain: S
Molecule details ›
Chain: S
Length: 29 nucleotides
Theoretical weight: 8.95 KDa
DNA (29-MER) Chain: T
Molecule details ›
Chain: T
Length: 29 nucleotides
Theoretical weight: 8.88 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-21138
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli