› 6vb2

X-ray diffraction
1.41Å resolution

HLA-B*15:02 complexed with a synthetic peptide

Released:
DOI: 10.2210/pdb6vb2/pdb
PDB entry 6vb2 coloured by chain, front view.
PDB entry 6vb2 coloured by chain, side view.
PDB entry 6vb2 coloured by chain, top view.
Source organisms:
Entry authors: Schutte RJ, Li D, Ostrov DA

Function and Biology Details

Reactions catalysed: 
A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H(2)O
A hydroperoxy icosatetraenoate = a hydroxy epoxy icosatrienoate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-123512 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: F4NBQ8 (Residues: 25-300; Coverage: 88%)
Gene name: HLA-B
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 96 amino acids
Theoretical weight: 11.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 22-117; Coverage: 97%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Hydroperoxide isomerase ALOXE3 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.17 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: Q9BYJ1 (Residues: 136-144; Coverage: 1%)
Gene name: ALOXE3

Ligands and Environments

4 bound ligands:
Ligand NA 1 x NA
Ligand GOL 2 x GOL
Ligand ACT 2 x ACT
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 50.849Å b: 81.407Å c: 110.065Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.198 0.232
Expression systems:
  • Escherichia coli
  • Not provided

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