› 6vpr

X-ray diffraction
2.2Å resolution

Crystal structure of the C-terminal domain of DENR

Released:
DOI: 10.2210/pdb6vpr/pdb
PDB entry 6vpr coloured by chain, front view.
PDB entry 6vpr coloured by chain, side view.
PDB entry 6vpr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the C-terminal domain of DENR.
Lomakin IB, De S, Wang J, Borkar AN, Steitz TA
Comput Struct Biotechnol J 18 696-704 (2020)
PMID: 32257053

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Density-regulated protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 198 amino acids
Theoretical weight: 22.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43583 (Residues: 1-198; Coverage: 100%)
Gene names: DENR, DRP1, H14
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand TLA 4 x TLA
Ligand SO4 3 x SO4
Ligand ACT 3 x ACT
Ligand HG 4 x HG
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6422
Unit cell:
a: 116.6Å b: 116.6Å c: 75.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.224 0.288
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion.
Chen et al. (2022)
1 more

1 mention without citation

Crystal structure of the C-terminal domain of DENR.
Lomakin et al. (2020)