› 6vvq

X-ray diffraction
3.09Å resolution

Human START domain of Acyl-coenzyme A thioesterase 11 (ACOT11) bound to Myristic Acid

Released:
DOI: 10.2210/pdb6vvq/pdb
PDB entry 6vvq coloured by chain, front view.
PDB entry 6vvq coloured by chain, side view.
PDB entry 6vvq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine.
Tillman MC, Imai N, Li Y, Khadka M, Okafor CD, Juneja P, Adhiyaman A, Hagen SJ, Cohen DE, Ortlund EA
Proc Natl Acad Sci U S A 117 22080-22089 (2020)
PMID: 32820071

Function and Biology Details

Reaction catalysed: 
Palmitoyl-CoA + H(2)O = CoA + palmitate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl-coenzyme A thioesterase 11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 258 amino acids
Theoretical weight: 29.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WXI4 (Residues: 339-543; Coverage: 34%)
Gene names: ACOT11, BFIT, KIAA0707, THEA
Sequence domains: START domain

Ligands and Environments

1 bound ligand:
Ligand MYR 1 x MYR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 65.082Å b: 70.984Å c: 127.224Å
α: 90° β: 96.133° γ: 90°
R-values:
R R work R free
0.223 0.221 0.263
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

HD-Zip IV transcription factors: Drivers of epidermal cell fate integrate metabolic signals.
Schrick et al. (2023)
6 other articles

1 mention without citation

Predicting allosteric pockets in protein biological assemblages.
Kumar et al. (2023)