Function and Biology Details
Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144159 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Processed angiotensin-converting enzyme 2
Molecule details ›
Chains: A, B
Length: 597 amino acids
Theoretical weight: 69.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Angiotensin-converting enzyme
Length: 597 amino acids
Theoretical weight: 69.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q9BYF1 (Residues: 19-615; Coverage: 76%)
Sequence domains: Angiotensin-converting enzyme
Spike protein S1
Molecule details ›
Chains: E, F
Length: 217 amino acids
Theoretical weight: 24.33 KDa
Source organisms:
UniProt:
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Length: 217 amino acids
Theoretical weight: 24.33 KDa
Source organisms:
- Severe acute respiratory syndrome coronavirus 2
- Severe acute respiratory syndrome-related coronavirus
UniProt:
- Canonical: P0DTC2 (Residues: 319-320, 455-518; Coverage: 5%)
- Canonical: P59594 (Residues: 308-441, 505-521; Coverage: 12%)
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Ligands and Environments
Experiments and Validation Details
X-ray source:
APS BEAMLINE 24-ID-E
Spacegroup:
P21
Expression system: Spodoptera frugiperda
