› 6w4s

Electron Microscopy
3.2Å resolution

Structure of apo human ferroportin in lipid nanodisc

Released:
DOI: 10.2210/pdb6w4s/pdb
PDB entry 6w4s coloured by chain, front view.
PDB entry 6w4s coloured by chain, side view.
PDB entry 6w4s coloured by chain, top view.
Source organisms:
Primary publication:
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A
Nature 586 807-811 (2020)
PMID: 32814342
Related structures: EMD-21539

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212781 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Solute carrier family 40 member 1 Chain: F
Molecule details ›
Chain: F
Length: 605 amino acids
Theoretical weight: 66.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NP59 (Residues: 1-571; Coverage: 100%)
Gene names: FPN, FPN1, IREG1, MSTP079, SLC11A3, SLC40A1
Sequence domains: Ferroportin1 (FPN1)
Fab45D8 Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.85 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Fab45D8 Light Chain Chain: L
Molecule details ›
Chain: L
Length: 218 amino acids
Theoretical weight: 24.01 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-21539
Expression systems:
  • Spodoptera frugiperda
  • Homo sapiens

Quick links

Citations

40 review citations

Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.
Nemeth et al. (2021)
39 more

10 mentions without citation

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Billesbølle et al. (2020)
9 more