› 6ww2

Electron Microscopy
3.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209556 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
anti-BRIL Fab Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 229 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
anti-Fab Nanobody Chain: K
Molecule details ›
Chain: K
Length: 123 amino acids
Theoretical weight: 13.39 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
anti-BRIL Fab Light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Frizzled-5; Soluble cytochrome b562 Chain: R
Molecule details ›
Chain: R
Length: 667 amino acids
Theoretical weight: 74.75 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q13467 (Residues: 27-428, 441-546; Coverage: 91%)
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
Gene names: C2orf31, FZD5, cybC
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-21927
Expression systems:
  • Escherichia coli
  • Homo sapiens

Quick links

Citations

7 review citations

New insights into GPCR coupling and dimerisation from cryo-EM structures.
Gusach et al. (2023)
6 more

17 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
16 more