6xa1

Electron Microscopy
2.8Å resolution

Structure of a drug-like compound stalled human translation termination complex

Released:
Source organism: Homo sapiens
Related structures: EMD-22085

Function and Biology Details

Reaction catalysed:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 83-mer (preferred)
PDBe Complex ID:
PDB-CPX-123204 (preferred)
Entry contents:
77 distinct polypeptide molecules
6 distinct RNA molecules
Macromolecules (83 distinct):
Large ribosomal subunit protein uL2 Chain: LA
Molecule details ›
Chain: LA
Length: 248 amino acids
Theoretical weight: 27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62917 (Residues: 2-249; Coverage: 97%)
Gene name: RPL8
Sequence domains:
Large ribosomal subunit protein uL3 Chain: LB
Molecule details ›
Chain: LB
Length: 396 amino acids
Theoretical weight: 45.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P39023 (Residues: 2-397; Coverage: 98%)
Gene names: OK/SW-cl.32, RPL3
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4 Chain: LC
Molecule details ›
Chain: LC
Length: 358 amino acids
Theoretical weight: 40.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P36578 (Residues: 1-358; Coverage: 84%)
Gene names: RPL1, RPL4
Sequence domains:
Large ribosomal subunit protein uL18 Chain: LD
Molecule details ›
Chain: LD
Length: 290 amino acids
Theoretical weight: 33.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P46777 (Residues: 2-291; Coverage: 98%)
Gene names: MSTP030, RPL5
Sequence domains:
Large ribosomal subunit protein eL6 Chain: LE
Molecule details ›
Chain: LE
Length: 247 amino acids
Theoretical weight: 28.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02878 (Residues: 42-288; Coverage: 86%)
Gene names: RPL6, TXREB1
Sequence domains:
Large ribosomal subunit protein uL30 Chain: LF
Molecule details ›
Chain: LF
Length: 225 amino acids
Theoretical weight: 26.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P18124 (Residues: 24-248; Coverage: 91%)
Gene name: RPL7
Sequence domains:
Large ribosomal subunit protein eL8 Chain: LG
Molecule details ›
Chain: LG
Length: 241 amino acids
Theoretical weight: 27.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62424 (Residues: 26-266; Coverage: 91%)
Gene names: RPL7A, SURF-3, SURF3
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein uL6 Chain: LH
Molecule details ›
Chain: LH
Length: 190 amino acids
Theoretical weight: 21.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P32969 (Residues: 1-190; Coverage: 99%)
Gene names: OK/SW-cl.103, RPL9, RPL9P7, RPL9P8, RPL9P9
Sequence domains: Ribosomal protein L6
Ribosomal protein uL16-like Chain: LI
Molecule details ›
Chain: LI
Length: 213 amino acids
Theoretical weight: 24.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96L21 (Residues: 2-214; Coverage: 100%)
Gene name: RPL10L
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL5 Chain: LJ
Molecule details ›
Chain: LJ
Length: 176 amino acids
Theoretical weight: 20.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62913 (Residues: 3-178; Coverage: 99%)
Gene name: RPL11
Sequence domains:
Large ribosomal subunit protein eL13 Chain: LL
Molecule details ›
Chain: LL
Length: 204 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P26373 (Residues: 2-205; Coverage: 97%)
Gene names: BBC1, OK/SW-cl.46, RPL13
Sequence domains: Ribosomal protein L13e
Large ribosomal subunit protein eL14 Chain: LM
Molecule details ›
Chain: LM
Length: 139 amino acids
Theoretical weight: 16.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P50914 (Residues: 2-140; Coverage: 65%)
Gene name: RPL14
Sequence domains: Ribosomal protein L14
Large ribosomal subunit protein eL15 Chain: LN
Molecule details ›
Chain: LN
Length: 203 amino acids
Theoretical weight: 24.08 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61313 (Residues: 2-204; Coverage: 100%)
Gene names: EC45, RPL15, TCBAP0781
Sequence domains: Ribosomal L15
Large ribosomal subunit protein uL13 Chain: LO
Molecule details ›
Chain: LO
Length: 201 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P40429 (Residues: 3-203; Coverage: 99%)
Gene name: RPL13A
Sequence domains: Ribosomal protein L13
Large ribosomal subunit protein uL22 Chain: LP
Molecule details ›
Chain: LP
Length: 153 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P18621 (Residues: 2-154; Coverage: 83%)
Gene name: RPL17
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein eL18 Chain: LQ
Molecule details ›
Chain: LQ
Length: 187 amino acids
Theoretical weight: 21.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07020 (Residues: 2-188; Coverage: 100%)
Gene name: RPL18
Sequence domains: Ribosomal protein 60S L18 and 50S L18e
Large ribosomal subunit protein eL19 Chain: LR
Molecule details ›
Chain: LR
Length: 187 amino acids
Theoretical weight: 22.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P84098 (Residues: 2-188; Coverage: 95%)
Gene name: RPL19
Sequence domains: Ribosomal protein L19e
Large ribosomal subunit protein eL20 Chain: LS
Molecule details ›
Chain: LS
Length: 175 amino acids
Theoretical weight: 20.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02543 (Residues: 2-176; Coverage: 99%)
Gene name: RPL18A
Sequence domains: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
Large ribosomal subunit protein eL21 Chain: LT
Molecule details ›
Chain: LT
Length: 159 amino acids
Theoretical weight: 18.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P46778 (Residues: 2-160; Coverage: 99%)
Gene name: RPL21
Sequence domains: Ribosomal protein L21e
Large ribosomal subunit protein eL22 Chain: LU
Molecule details ›
Chain: LU
Length: 101 amino acids
Theoretical weight: 11.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7Z4W8 (Residues: 17-117; Coverage: 79%)
Sequence domains: Ribosomal L22e protein family
Large ribosomal subunit protein uL14 Chain: LV
Molecule details ›
Chain: LV
Length: 131 amino acids
Theoretical weight: 13.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62829 (Residues: 10-140; Coverage: 94%)
Gene name: RPL23
Sequence domains: Ribosomal protein L14p/L23e
Large ribosomal subunit protein eL24 Chain: LW
Molecule details ›
Chain: LW
Length: 124 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P83731 (Residues: 1-124; Coverage: 79%)
Gene name: RPL24
Sequence domains: Ribosomal protein L24e
Large ribosomal subunit protein uL23 Chain: LX
Molecule details ›
Chain: LX
Length: 120 amino acids
Theoretical weight: 13.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62750 (Residues: 37-156; Coverage: 77%)
Gene name: RPL23A
Sequence domains:
Large ribosomal subunit protein uL24 Chain: LY
Molecule details ›
Chain: LY
Length: 134 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61254 (Residues: 1-134; Coverage: 92%)
Gene name: RPL26
Sequence domains:
Large ribosomal subunit protein eL27 Chain: LZ
Molecule details ›
Chain: LZ
Length: 135 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61353 (Residues: 2-136; Coverage: 99%)
Gene name: RPL27
Sequence domains:
Large ribosomal subunit protein uL15 Chain: La
Molecule details ›
Chain: La
Length: 147 amino acids
Theoretical weight: 16.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P46776 (Residues: 2-148; Coverage: 99%)
Gene name: RPL27A
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein eL29 Chain: Lb
Molecule details ›
Chain: Lb
Length: 121 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P47914 (Residues: 2-122; Coverage: 76%)
Gene name: RPL29
Sequence domains: Ribosomal L29e protein family
Large ribosomal subunit protein eL30 Chain: Lc
Molecule details ›
Chain: Lc
Length: 98 amino acids
Theoretical weight: 10.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62888 (Residues: 9-106; Coverage: 85%)
Gene name: RPL30
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL31 Chain: Ld
Molecule details ›
Chain: Ld
Length: 107 amino acids
Theoretical weight: 12.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62899 (Residues: 18-124; Coverage: 86%)
Gene name: RPL31
Sequence domains: Ribosomal protein L31e
Large ribosomal subunit protein eL32 Chain: Le
Molecule details ›
Chain: Le
Length: 128 amino acids
Theoretical weight: 15.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62910 (Residues: 2-129; Coverage: 95%)
Gene names: PP9932, RPL32
Sequence domains: Ribosomal protein L32
Large ribosomal subunit protein eL33 Chain: Lf
Molecule details ›
Chain: Lf
Length: 109 amino acids
Theoretical weight: 12.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P18077 (Residues: 2-110; Coverage: 99%)
Gene names: GIG33, RPL35A
Sequence domains: Ribosomal protein L35Ae
Large ribosomal subunit protein eL34 Chain: Lg
Molecule details ›
Chain: Lg
Length: 114 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P49207 (Residues: 2-115; Coverage: 97%)
Gene name: RPL34
Sequence domains: Ribosomal protein L34e
Large ribosomal subunit protein uL29 Chain: Lh
Molecule details ›
Chain: Lh
Length: 122 amino acids
Theoretical weight: 14.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42766 (Residues: 2-123; Coverage: 99%)
Gene name: RPL35
Sequence domains: Ribosomal L29 protein
Large ribosomal subunit protein eL36 Chain: Li
Molecule details ›
Chain: Li
Length: 102 amino acids
Theoretical weight: 11.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y3U8 (Residues: 2-103; Coverage: 97%)
Gene name: RPL36
Sequence domains: Ribosomal protein L36e
Large ribosomal subunit protein eL37 Chain: Lj
Molecule details ›
Chain: Lj
Length: 86 amino acids
Theoretical weight: 10.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61927 (Residues: 2-87; Coverage: 89%)
Gene name: RPL37
Sequence domains: Ribosomal protein L37e
Large ribosomal subunit protein eL38 Chain: Lk
Molecule details ›
Chain: Lk
Length: 69 amino acids
Theoretical weight: 8.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P63173 (Residues: 2-70; Coverage: 99%)
Gene name: RPL38
Sequence domains: Ribosomal L38e protein family
Large ribosomal subunit protein eL39 Chain: Ll
Molecule details ›
Chain: Ll
Length: 50 amino acids
Theoretical weight: 6.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62891 (Residues: 2-51; Coverage: 98%)
Gene name: RPL39
Sequence domains: Ribosomal L39 protein
Large ribosomal subunit protein eL40 Chain: Lm
Molecule details ›
Chain: Lm
Length: 52 amino acids
Theoretical weight: 6.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62987 (Residues: 77-128; Coverage: 41%)
Gene names: UBA52, UBCEP2
Sequence domains: Ribosomal L40e family
Small ribosomal subunit protein eS32 Chain: Ln
Molecule details ›
Chain: Ln
Length: 24 amino acids
Theoretical weight: 3.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62945 (Residues: 1-24; Coverage: 96%)
Gene name: RPL41
Sequence domains: Ribosomal protein L41
Large ribosomal subunit protein eL42 Chain: Lo
Molecule details ›
Chain: Lo
Length: 105 amino acids
Theoretical weight: 12.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P83881 (Residues: 2-106; Coverage: 99%)
Gene names: GIG15, MIG6, RPL36A, RPL44
Sequence domains: Ribosomal protein L44
Large ribosomal subunit protein eL43 Chain: Lp
Molecule details ›
Chain: Lp
Length: 91 amino acids
Theoretical weight: 10.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61513 (Residues: 2-92; Coverage: 99%)
Gene name: RPL37A
Sequence domains: Ribosomal L37ae protein family
Large ribosomal subunit protein eL28 Chain: Lr
Molecule details ›
Chain: Lr
Length: 125 amino acids
Theoretical weight: 14.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P46779 (Residues: 2-126; Coverage: 91%)
Gene name: RPL28
Sequence domains: Ribosomal L28e protein family
Small ribosomal subunit protein uS2 Chain: SA
Molecule details ›
Chain: SA
Length: 216 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08865 (Residues: 2-217; Coverage: 73%)
Gene names: LAMBR, LAMR1, RPSA
Sequence domains: Ribosomal protein S2
Small ribosomal subunit protein eS1 Chain: SB
Molecule details ›
Chain: SB
Length: 211 amino acids
Theoretical weight: 24.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61247 (Residues: 22-232; Coverage: 80%)
Gene names: FTE1, MFTL, RPS3A
Sequence domains: Ribosomal S3Ae family
Small ribosomal subunit protein uS3 Chain: SD
Molecule details ›
Chain: SD
Length: 224 amino acids
Theoretical weight: 24.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23396 (Residues: 4-227; Coverage: 92%)
Gene names: OK/SW-cl.26, RPS3
Sequence domains:
Small ribosomal subunit protein eS4, X isoform Chain: SE
Molecule details ›
Chain: SE
Length: 258 amino acids
Theoretical weight: 29.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62701 (Residues: 2-259; Coverage: 98%)
Gene names: CCG2, RPS4, RPS4X, SCAR
Sequence domains:
Small ribosomal subunit protein uS7 Chain: SF
Molecule details ›
Chain: SF
Length: 189 amino acids
Theoretical weight: 21.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P46782 (Residues: 16-204; Coverage: 93%)
Gene name: RPS5
Sequence domains: Ribosomal protein S7p/S5e
Small ribosomal subunit protein eS7 Chain: SH
Molecule details ›
Chain: SH
Length: 189 amino acids
Theoretical weight: 21.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62081 (Residues: 6-194; Coverage: 97%)
Gene name: RPS7
Sequence domains: Ribosomal protein S7e
Small ribosomal subunit protein eS8 Chain: SI
Molecule details ›
Chain: SI
Length: 205 amino acids
Theoretical weight: 23.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62241 (Residues: 2-206; Coverage: 99%)
Gene names: OK/SW-cl.83, RPS8
Sequence domains: Ribosomal protein S8e
Small ribosomal subunit protein eS10 Chain: SK
Molecule details ›
Chain: SK
Length: 95 amino acids
Theoretical weight: 11.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P46783 (Residues: 1-95; Coverage: 58%)
Gene name: RPS10
Sequence domains: Plectin/S10 domain
Small ribosomal subunit protein uS17 Chain: SL
Molecule details ›
Chain: SL
Length: 150 amino acids
Theoretical weight: 17.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62280 (Residues: 2-151; Coverage: 95%)
Gene name: RPS11
Sequence domains:
Small ribosomal subunit protein uS19 Chain: SP
Molecule details ›
Chain: SP
Length: 131 amino acids
Theoretical weight: 15.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62841 (Residues: 13-143; Coverage: 90%)
Gene names: RIG, RPS15
Sequence domains: Ribosomal protein S19
Small ribosomal subunit protein uS9 Chain: SQ
Molecule details ›
Chain: SQ
Length: 140 amino acids
Theoretical weight: 15.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62249 (Residues: 7-146; Coverage: 96%)
Gene name: RPS16
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein eS17 Chain: SR
Molecule details ›
Chain: SR
Length: 131 amino acids
Theoretical weight: 15.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08708 (Residues: 2-132; Coverage: 97%)
Gene names: RPS17, RPS17L
Sequence domains: Ribosomal S17
Small ribosomal subunit protein uS13 Chain: SS
Molecule details ›
Chain: SS
Length: 143 amino acids
Theoretical weight: 16.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62269 (Residues: 3-145; Coverage: 94%)
Gene names: D6S218E, RPS18
Sequence domains: Ribosomal protein S13/S18
Small ribosomal subunit protein eS19 Chain: ST
Molecule details ›
Chain: ST
Length: 141 amino acids
Theoretical weight: 15.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P39019 (Residues: 2-142; Coverage: 97%)
Gene name: RPS19
Sequence domains: Ribosomal protein S19e
Small ribosomal subunit protein uS10 Chain: SU
Molecule details ›
Chain: SU
Length: 100 amino acids
Theoretical weight: 11.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P60866 (Residues: 17-116; Coverage: 84%)
Gene name: RPS20
Sequence domains: Ribosomal protein S10p/S20e
Small ribosomal subunit protein eS21 Chain: SV
Molecule details ›
Chain: SV
Length: 84 amino acids
Theoretical weight: 9.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P63220 (Residues: 1-83; Coverage: 100%)
Gene name: RPS21
Sequence domains: Ribosomal protein S21e
Small ribosomal subunit protein uS12 Chain: SX
Molecule details ›
Chain: SX
Length: 139 amino acids
Theoretical weight: 15.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62266 (Residues: 2-140; Coverage: 97%)
Gene name: RPS23
Sequence domains: Ribosomal protein S12/S23
Small ribosomal subunit protein eS26 Chain: Sa
Molecule details ›
Chain: Sa
Length: 99 amino acids
Theoretical weight: 11.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62854 (Residues: 2-100; Coverage: 86%)
Gene name: RPS26
Sequence domains: Ribosomal protein S26e
Small ribosomal subunit protein eS28 Chain: Sc
Molecule details ›
Chain: Sc
Length: 61 amino acids
Theoretical weight: 6.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62857 (Residues: 8-68; Coverage: 88%)
Gene name: RPS28
Sequence domains: Ribosomal protein S28e
Small ribosomal subunit protein uS14 Chain: Sd
Molecule details ›
Chain: Sd
Length: 55 amino acids
Theoretical weight: 6.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62273 (Residues: 2-56; Coverage: 98%)
Gene name: RPS29
Sequence domains: Ribosomal protein S14p/S29e
Small ribosomal subunit protein RACK1 Chain: Sg
Molecule details ›
Chain: Sg
Length: 313 amino acids
Theoretical weight: 34.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P63244 (Residues: 2-314; Coverage: 99%)
Gene names: GNB2L1, HLC7, PIG21, RACK1
Sequence domains: WD domain, G-beta repeat
Small ribosomal subunit protein uS5 Chain: SC
Molecule details ›
Chain: SC
Length: 220 amino acids
Theoretical weight: 24.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15880 (Residues: 59-278; Coverage: 75%)
Gene names: RPS2, RPS4
Sequence domains:
Small ribosomal subunit protein eS6 Chain: SG
Molecule details ›
Chain: SG
Length: 228 amino acids
Theoretical weight: 26.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62753 (Residues: 1-228; Coverage: 92%)
Gene names: OK/SW-cl.2, RPS6
Sequence domains: Ribosomal protein S6e
Small ribosomal subunit protein uS4 Chain: SJ
Molecule details ›
Chain: SJ
Length: 180 amino acids
Theoretical weight: 21.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P46781 (Residues: 2-181; Coverage: 93%)
Gene name: RPS9
Sequence domains:
Small ribosomal subunit protein eS12 Chain: SM
Molecule details ›
Chain: SM
Length: 120 amino acids
Theoretical weight: 13.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P25398 (Residues: 13-132; Coverage: 91%)
Gene name: RPS12
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Small ribosomal subunit protein uS15 Chain: SN
Molecule details ›
Chain: SN
Length: 150 amino acids
Theoretical weight: 17.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62277 (Residues: 2-151; Coverage: 99%)
Gene name: RPS13
Sequence domains:
Small ribosomal subunit protein uS11 Chain: SO
Molecule details ›
Chain: SO
Length: 135 amino acids
Theoretical weight: 14.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62263 (Residues: 17-151; Coverage: 89%)
Gene names: PRO2640, RPS14
Sequence domains: Ribosomal protein S11
Small ribosomal subunit protein uS8 Chain: SW
Molecule details ›
Chain: SW
Length: 129 amino acids
Theoretical weight: 14.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62244 (Residues: 2-130; Coverage: 99%)
Gene names: OK/SW-cl.82, RPS15A
Sequence domains: Ribosomal protein S8
Small ribosomal subunit protein eS24 Chain: SY
Molecule details ›
Chain: SY
Length: 122 amino acids
Theoretical weight: 14.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62847 (Residues: 4-125; Coverage: 92%)
Gene name: RPS24
Sequence domains: Ribosomal protein S24e
Small ribosomal subunit protein eS25 Chain: SZ
Molecule details ›
Chain: SZ
Length: 70 amino acids
Theoretical weight: 7.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62851 (Residues: 43-112; Coverage: 56%)
Gene name: RPS25
Sequence domains: S25 ribosomal protein
Small ribosomal subunit protein eS27 Chain: Sb
Molecule details ›
Chain: Sb
Length: 82 amino acids
Theoretical weight: 9.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42677 (Residues: 2-83; Coverage: 98%)
Gene names: MPS1, RPS27
Sequence domains: Ribosomal protein S27
FAU ubiquitin like and ribosomal protein S30 fusion Chain: Se
Molecule details ›
Chain: Se
Length: 54 amino acids
Theoretical weight: 6.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: E9PR30 (Residues: 44-97; Coverage: 55%)
Gene name: FAU
Sequence domains: Ribosomal protein S30
Small ribosomal subunit protein eS31 Chain: Sf
Molecule details ›
Chain: Sf
Length: 63 amino acids
Theoretical weight: 7.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62979 (Residues: 89-151; Coverage: 40%)
Gene names: RPS27A, UBA80, UBCEP1
Sequence domains: Ribosomal protein S27a
Eukaryotic peptide chain release factor subunit 1 Chain: j
Molecule details ›
Chain: j
Length: 411 amino acids
Theoretical weight: 46.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62495 (Residues: 11-421; Coverage: 94%)
Gene names: ERF1, ETF1, RF1, SUP45L1
Sequence domains:
Stalled Nascent chain Chain: NC
Molecule details ›
Chain: NC
Length: 25 amino acids
Theoretical weight: 2.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
28S ribosomal RNA Chain: L5
Molecule details ›
Chain: L5
Length: 3510 nucleotides
Theoretical weight: 1138.22 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
5S ribosomal RNA Chain: L7
Molecule details ›
Chain: L7
Length: 120 nucleotides
Theoretical weight: 38.69 KDa
Sequence domains: 5S ribosomal RNA
5.8S ribosomal RNA Chain: L8
Molecule details ›
Chain: L8
Length: 155 nucleotides
Theoretical weight: 49.85 KDa
Sequence domains: 5.8S ribosomal RNA
18S Ribosomal RNA Chain: S2
Molecule details ›
Chain: S2
Length: 1590 nucleotides
Theoretical weight: 514.09 KDa
Sequence domains: Eukaryotic small subunit ribosomal RNA
P-tRNA Chain: Bv
Molecule details ›
Chain: Bv
Length: 76 nucleotides
Theoretical weight: 24.64 KDa
Sequence domains: tRNA
Messenger RNA Chain: k
Molecule details ›
Chain: k
Length: 13 nucleotides
Theoretical weight: 4.05 KDa

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-22085
Expression system: Homo sapiens