› 6xe6

Electron Microscopy
4.54Å resolution

Structure of Human Dispatched-1 (DISP1)

Released:
DOI: 10.2210/pdb6xe6/pdb
PDB entry 6xe6 coloured by chain, front view.
PDB entry 6xe6 coloured by chain, side view.
PDB entry 6xe6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis.
Chen H, Liu Y, Li X
Life Sci Alliance 3 (2020)
PMID: 32646883
Related structures: EMD-22144

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188491 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein dispatched homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 1096 amino acids
Theoretical weight: 124.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96F81 (Residues: 172-1249; Coverage: 71%)
Gene names: DISP1, DISPA
Sequence domains: Patched family

Ligands and Environments

2 bound ligands:
Ligand Y01 5 x Y01
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.54Å
Relevant EMDB volumes: EMD-22144
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Dispatching plasma membrane cholesterol and Sonic Hedgehog dispatch: two sides of the same coin?
Ehring et al. (2021)
3 more

2 mentions without citation

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.
Alav et al. (2021)
1 more