› 6xis

Electron Microscopy
3.9Å resolution

Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in apo form

Released:
DOI: 10.2210/pdb6xis/pdb
PDB entry 6xis coloured by chain, front view.
PDB entry 6xis coloured by chain, side view.
PDB entry 6xis coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels.
Niu Y, Tao X, Touhara KK, MacKinnon R
Elife 9 (2020)
PMID: 32844743
Related structures: EMD-22199

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
G protein-activated inward rectifier potassium channel 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 340 amino acids
Theoretical weight: 39.06 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P48542 (Residues: 52-380; Coverage: 77%)
Gene names: Girk2, Kcnj6, Kcnj7, W
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-22199
Expression system: Komagataella pastoris

Quick links

Citations

10 review citations

Structures and Dynamics of Native-State Transmembrane Protein Targets and Bound Lipids.
Overduin et al. (2021)
9 more

2 mentions without citation

Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels.
Niu et al. (2020)
1 more