› 6y22

X-ray diffraction
2.07Å resolution

RING-DTC domains of Deltex 2, Form 1

Released:
DOI: 10.2210/pdb6y22/pdb
PDB entry 6y22 coloured by chain, front view.
PDB entry 6y22 coloured by chain, side view.
PDB entry 6y22 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Ahmed SF, Buetow L, Gabrielsen M, Lilla S, Chatrin C, Sibbet GJ, Zanivan S, Huang DT
Sci Adv 6 (2020)
PMID: 32937373

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183194 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable E3 ubiquitin-protein ligase DTX2 Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 25.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86UW9 (Residues: 390-622; Coverage: 38%)
Gene names: DTX2, KIAA1528, RNF58
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3221
Unit cell:
a: 106.418Å b: 106.418Å c: 74.669Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.179 0.208
Expression system: Escherichia coli

Quick links

Citations

9 review citations

An expanded lexicon for the ubiquitin code.
Dikic et al. (2023)
8 more

1 mention without citation

DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Ahmed et al. (2020)