› 6y73

X-ray diffraction
1.7Å resolution

The crystal structure of human MACROD2 in space group P43

Released:
DOI: 10.2210/pdb6y73/pdb
PDB entry 6y73 coloured by chain, front view.
PDB entry 6y73 coloured by chain, side view.
PDB entry 6y73 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Multiple crystal forms of human MacroD2.
Wazir S, Maksimainen MM, Lehtiö L
Acta Crystallogr F Struct Biol Commun 76 477-482 (2020)
PMID: 33006575

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106766 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribose glycohydrolase MACROD2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 366 amino acids
Theoretical weight: 40.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A1Z1Q3 (Residues: 7-243; Coverage: 56%)
Gene names: C20orf133, MACROD2
Sequence domains: Macro domain

Ligands and Environments

3 bound ligands:
Ligand GOL 5 x GOL
Ligand TLA 5 x TLA
Ligand DMS 2 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P43
Unit cell:
a: 96.78Å b: 96.78Å c: 261.09Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.203
Expression system: Escherichia coli

Quick links

Citations

2 mentions without citation

pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data science.
Guerra et al. (2021)
1 more