6yxq

X-ray diffraction
2.7Å resolution

Crystal structure of a DNA repair complex ASCC3-ASCC2

Released:

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-185374 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activating signal cointegrator 1 complex subunit 3 Chain: A
Molecule details ›
Chain: A
Length: 211 amino acids
Theoretical weight: 23.93 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8N3C0 (Residues: 1-207; Coverage: 9%)
Gene names: ASCC3, HELIC1, RQT2
Activating signal cointegrator 1 complex subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 438 amino acids
Theoretical weight: 50.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H1I8 (Residues: 2-434; Coverage: 57%)
Gene names: ASC1P100, ASCC2, RQT3

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: I4
Unit cell:
a: 158.108Å b: 158.108Å c: 69.365Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.247
Expression systems:
  • Trichoplusia ni
  • Escherichia coli