› 7atu

X-ray diffraction
2.8Å resolution

The LIMK1 Kinase Domain Bound To LIJTF500025

Released:
DOI: 10.2210/pdb7atu/pdb
PDB entry 7atu coloured by chain, front view.
PDB entry 7atu coloured by chain, side view.
PDB entry 7atu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mathea S, Chatterjee D, Preuss F, Yamamoto S, Tawada M, Nomura I, Takagi T, Ahmed M, Little W, Mueller-Knapp S, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156847 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
LIM domain kinase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 310 amino acids
Theoretical weight: 35.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53667 (Residues: 330-637; Coverage: 48%)
Gene names: LIMK, LIMK1
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand RXN 4 x RXN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 85.234Å b: 83.838Å c: 98.029Å
α: 90° β: 92.339° γ: 90°
R-values:
R R work R free
0.244 0.24 0.316
Expression system: Spodoptera frugiperda

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