7bqv

X-ray diffraction
1.8Å resolution

Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-188757 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein cereblon Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96SW2 (Residues: 318-426; Coverage: 25%)
Gene names: AD-006, CRBN
Sequence domains: Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
Sal-like protein 4 Chain: B
Molecule details ›
Chain: B
Length: 24 amino acids
Theoretical weight: 2.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UJQ4 (Residues: 410-432; Coverage: 2%)
Gene names: SALL4, ZNF797
Sequence domains: Zinc finger, C2H2 type

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: C2221
Unit cell:
a: 83.621Å b: 93.895Å c: 43.682Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.223
Expression system: Escherichia coli