› 7cfs

Electron Microscopy
3.56Å resolution

Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0

Released:
DOI: 10.2210/pdb7cfs/pdb
PDB entry 7cfs coloured by chain, front view.
PDB entry 7cfs coloured by chain, side view.
PDB entry 7cfs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Sun D, Liu S, Li S, Zhang M, Yang F, Wen M, Shi P, Wang T, Pan M, Chang S, Zhang X, Zhang L, Tian C, Liu L
Elife 9 (2020)
PMID: 32915133
Related structures: EMD-30346

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160250 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 477 amino acids
Theoretical weight: 54.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P78348 (Residues: 1-468; Coverage: 89%)
Gene names: ACCN2, ASIC1, BNAC2
Sequence domains: Amiloride-sensitive sodium channel

Ligands and Environments

3 bound ligands:
Ligand NAG 6 x NAG
Ligand Y01 3 x Y01
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.56Å
Relevant EMDB volumes: EMD-30346
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Acid-Sensing Ion Channels and Mechanosensation.
Ruan et al. (2021)
4 more

2 mentions without citation

Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer.
Otero-Sobrino et al. (2023)
1 more