7cft

Electron Microscopy
3.9Å resolution

Cryo-EM strucutre of human acid-sensing ion channel 1a in complex with snake toxin Mambalgin1 at pH 8.0

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-143615 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 477 amino acids
Theoretical weight: 54.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P78348 (Residues: 1-468; Coverage: 89%)
Gene names: ACCN2, ASIC1, BNAC2
Sequence domains: Amiloride-sensitive sodium channel
Mambalgin-1 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 57 amino acids
Theoretical weight: 6.57 KDa
Source organism: Dendroaspis polylepis polylepis
Expression system: Not provided
UniProt:
  • Canonical: P0DKR6 (Residues: 22-78; Coverage: 100%)

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-30347
Expression systems:
  • Spodoptera frugiperda
  • Not provided