› 7cmo

X-ray diffraction
3.4Å resolution

Crystal structure of human inorganic pyrophosphatase

Released:
DOI: 10.2210/pdb7cmo/pdb
PDB entry 7cmo coloured by chain, front view.
PDB entry 7cmo coloured by chain, side view.
PDB entry 7cmo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical characterization of inorganic pyrophosphatase from Homo sapiens.
Hu F, Huang Z, Zheng S, Wu Q, Chen Y, Lin H, Huang W, Li L
Biochem Biophys Res Commun 533 1115-1121 (2020)
PMID: 33036755

Function and Biology Details

Reaction catalysed: 
Diphosphate + H(2)O = 2 phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172229 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inorganic pyrophosphatase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 289 amino acids
Theoretical weight: 32.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15181 (Residues: 1-289; Coverage: 100%)
Gene names: IOPPP, PP, PPA1
Sequence domains: Inorganic pyrophosphatase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 49.905Å b: 135.041Å c: 212.707Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.277
Expression system: Escherichia coli BL21(DE3)

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Citations

2 citation in other articles

Computational innovation of in situ metallic elements with zirconia as a novel possible carrier for chemotherapeutic medication.
Issa et al. (2023)
1 more

1 mention without citation

PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors.
Wang et al. (2022)