› 7d61

Electron Microscopy
2.8Å resolution

Cryo-EM Structure of human CALHM5 in the presence of EDTA

Released:
DOI: 10.2210/pdb7d61/pdb
PDB entry 7d61 coloured by chain, front view.
PDB entry 7d61 coloured by chain, side view.
PDB entry 7d61 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of human calcium homeostasis modulator 5.
Liu J, Wan F, Jin Q, Li X, Bhat EA, Guo J, Lei M, Guan F, Wu J, Ye S
Cell Discov 6 81 (2020)
PMID: 33298887
Related structures: EMD-30587

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo undecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium homeostasis modulator protein 5 Chains: A, B, C, D, E, F, G, H, I, J, K
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K
Length: 288 amino acids
Theoretical weight: 32.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N5C1 (Residues: 1-288; Coverage: 93%)
Gene names: C6orf188, CALHM5, FAM26E
Sequence domains: Calcium homeostasis modulator

Ligands and Environments

1 bound ligand:
Ligand PA8 55 x PA8
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-30587
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Human CALHM5: Insight in large pore lipid gating ATP channel and associated neurological pathologies.
Bhat et al. (2021)
1 more

1 mention without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)