› 7jtl

X-ray diffraction
2.04Å resolution

Structure of SARS-CoV-2 ORF8 accessory protein

Released:
DOI: 10.2210/pdb7jtl/pdb
PDB entry 7jtl coloured by chain, front view.
PDB entry 7jtl coloured by chain, side view.
PDB entry 7jtl coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein.
Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH
Proc Natl Acad Sci U S A 118 (2021)
PMID: 33361333

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144996 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ORF8 protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 12.22 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTC8 (Residues: 18-121; Coverage: 98%)
Gene name: 8
Sequence domains: Betacoronavirus NS8 protein

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P41212
Unit cell:
a: 44.258Å b: 44.258Å c: 264.111Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.217 0.257
Expression system: Escherichia coli

Quick links

Citations

40 review citations

Emerging SARS-CoV-2 variants of concern and potential intervention approaches.
Khateeb et al. (2021)
39 more

49 mentions without citation

Structural insights into SARS-CoV-2 proteins.
Arya et al. (2021)
48 more