› 7lpd

Electron Microscopy
3.55Å resolution

Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2

Released:
DOI: 10.2210/pdb7lpd/pdb
PDB entry 7lpd coloured by chain, front view.
PDB entry 7lpd coloured by chain, side view.
PDB entry 7lpd coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Heat-dependent opening of TRPV1 in the presence of capsaicin.
Kwon DH, Zhang F, Suo Y, Bouvette J, Borgnia MJ, Lee SY
Nat Struct Mol Biol 28 554-563 (2021)
PMID: 34239123
Related structures: EMD-23478

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128685 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 868 amino acids
Theoretical weight: 98.72 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: O35433 (Residues: 1-838; Coverage: 100%)
Gene names: Trpv1, Vr1, Vr1l
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand LBN 8 x LBN
Ligand 6OU 12 x 6OU
Ligand 4DY 4 x 4DY
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.55Å
Relevant EMDB volumes: EMD-23478
Expression system: Homo sapiens

Quick links

Citations

12 review citations

A bibliometrics analysis and visualization study of TRPV1 channel.
Gao et al. (2023)
11 more

4 mentions without citation

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.
Yelshanskaya et al. (2022)
3 more