Ec number : 1.8.1.4
 
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Entry Information
Entry status  (1)
REL
(52)
 
Experimental methods  (3)
X-ray diffraction
(50)
Electron Microscopy
(1)
Solution NMR
(1)
 
Authors  (204)
Adam-Vizi V
(12)
Ambrus A
(12)
Szabo E
(12)
Torocsik B
(12)
Weiss MS
(12)
Zambo Z
(11)
Wilk P
(10)
Jordan F
(9)
Nagy B
(9)
Arjunan P
(8)
Bui D
(8)
Furey W
(8)
Montfort WR
(8)
Weichsel A
(8)
Hubert A
(7)
Bryk R
(6)
Anderson WF
(5)
Center for Structural Genomics of Infectious Diseases (CSGID)
(5)
Grimshaw S
(5)
Kamiya N
(5)
Lima CD
(5)
Minasov G
(5)
Nakai T
(5)
Arango N
(4)
Brautigam CA
(4)
Chuang DT
(4)
Chuang JL
(4)
Dubrovska I
(4)
Hol WG
(4)
Kiryukhina O
(4)
Kwon K
(4)
Nathan C
(4)
RIKEN Structural Genomics/Proteomics Initiative (RSGI)
(4)
Shuvalova L
(4)
Ginn J
(3)
Glasser NR
(3)
Hol WGJ
(3)
Hoy JA
(3)
Joachimiak A
(3)
Machius M
(3)
Mattevi A
(3)
Michino M
(3)
Newman DK
(3)
Satchell KJF
(3)
Sekiguchi T
(3)
Sun S
(3)
Takenaka A
(3)
Tomchick DR
(3)
Wang BX
(3)
Adachi W
(2)
Almo SC
(2)
Fourme R
(2)
Huggins DJ
(2)
Kahn R
(2)
Mizsei R
(2)
Nemes-Nikodem E
(2)
Obmolova G
(2)
Ozohanics O
(2)
Padron G
(2)
Park YH
(2)
Patel MS
(2)
Perham RN
(2)
Reed LJ
(2)
Suzuki K
(2)
Vass KR
(2)
Wawrzak Z
(2)
Wynn RM
(2)
Zrupko E
(2)
Abendroth J
(1)
Allen MD
(1)
Alvarez A
(1)
Aso K
(1)
Bain KT
(1)
Balakrishnan A
(1)
Baxt L
(1)
Beautrait A
(1)
Betzel C
(1)
Bonanno JB
(1)
Bourguignon J
(1)
Boyles NA
(1)
Broadhurst RW
(1)
Buglino JA
(1)
Burley SK
(1)
Chamala S
(1)
Chandrasekhar K
(1)
Chuang JC
(1)
Ciszak EM
(1)
Cohen-Addad C
(1)
Dementiev A
(1)
Dementiev AA
(1)
Douce R
(1)
Dranow DM
(1)
Edwards TE
(1)
Evans B
(1)
Faure M
(1)
Ficner R
(1)
Foley M
(1)
Foti R
(1)
Fuller C
(1)
Gizzi A
(1)
 
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Homo / hetero assembly  (2)
homo
(45)
hetero
(7)
 
Assembly composition  (2)
protein structure
(45)
protein/protein complex
(7)
 
Assembly polymer count  (4)
dimer
(43)
trimer
(7)
monomer
(1)
tetramer
(1)
 
Resolution distribution
1.0 - 1.5
(3)
1.5 - 2
(18)
2.0 - 2.5
(21)
2.5 - 3
(7)
3.0 - 3.5
(1)
4.0 - 4.5
(1)
 
Release year distribution
1990 - 1995
(3)
1995 - 2000
(4)
2000 - 2005
(8)
2005 - 2010
(14)
2010 - 2015
(7)
2015 - 2020
(19)
2020 - 2025
(6)
 
Journal  (15)
To be published
(17)
Hum Mol Genet
(7)
J Biol Chem
(7)
J Mol Biol
(5)
Biochemistry
(2)
Eur J Biochem
(2)
Free Radic Biol Med
(2)
Int J Mol Sci
(2)
Structure
(2)
ACS Bio Med Chem Au
(1)
ACS Infect Dis
(1)
Acta Crystallogr D Biol Crystallogr
(1)
J Biochem
(1)
Not published
(1)
Proteins
(1)
 
Macromolecules
Organism superkingdom  (3)
Bacteria
(30)
Eukaryota
(21)
Archaea
(1)
 
Organism name  (20)
Homo sapiens
(17)
Mycobacterium tuberculosis
(6)
Thermus thermophilus HB8
(5)
Neisseria meningitidis
(3)
Pseudomonas aeruginosa UCBPP-PA14
(3)
Escherichia coli
(2)
Pseudomonas putida KT2440
(2)
Saccharomyces cerevisiae
(2)
Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841
(1)
Azotobacter vinelandii
(1)
Bordetella pertussis Tohama I
(1)
Burkholderia cenocepacia J2315
(1)
Elizabethkingia anophelis NUHP1
(1)
Geobacillus stearothermophilus
(1)
Pisum sativum
(1)
Pseudomonas fluorescens
(1)
Pseudomonas putida
(1)
Saccharolobus solfataricus
(1)
Sinorhizobium meliloti 1021
(1)
Trypanosoma cruzi
(1)
 
Molecule type  (1)
Protein
(52)
 
Gene names  (204)
DLD
(17)
GCSL
(17)
LAD
(17)
PHE3
(17)
lpd
(9)
MTV038.06
(6)
Rv0462
(6)
lpdC
(6)
lpdG
(5)
TTHA0233
(3)
lpdA
(3)
DHLP1
(2)
LPD
(2)
LPD1
(2)
PA14_43970
(2)
PP_4187
(2)
TTHA0287
(2)
YFL018C
(2)
lpdA2
(2)
lpdV
(2)
m-6
(2)
A2J79_001385
(1)
A5U30_000356
(1)
ABE91_003360
(1)
ACU57_15945
(1)
AWP47_05280
(1)
B6R15_000279
(1)
B6R31_002519
(1)
BANRA_00587
(1)
BANRA_02325
(1)
BANRA_04362
(1)
BCAL1215
(1)
BCB93_001533
(1)
BD94_2540
(1)
BG944_001924
(1)
BGM66_002919
(1)
BK300_10635
(1)
BK383_14290
(1)
BKL28_001134
(1)
BMT50_04275
(1)
BMT91_01630
(1)
BP1126
(1)
BRV02_001637
(1)
BTB68_000291
(1)
BTQ06_06200
(1)
BXT93_12600
(1)
BvCmsKKP061_01687
(1)
C0P57_002293
(1)
C1Q91_003300
(1)
C2M16_10515
(1)
C2R31_000678
(1)
C3F40_12535
(1)
C6669_04550
(1)
C719_003153
(1)
C7B02_09450
(1)
C9160_13845
(1)
C9194_10960
(1)
C9Z68_04515
(1)
CCS08_22875
(1)
CF22_002815
(1)
CG702_01665
(1)
CIG67_21415
(1)
CQ842_03155
(1)
CQ842_07470
(1)
CR538_20930
(1)
CTR35_001606
(1)
CWS33_09330
(1)
D3G36_13690
(1)
D4M65_00455
(1)
D4N09_07080
(1)
D9D43_02570
(1)
D9E49_02405
(1)
D9J61_17010
(1)
DD762_00810
(1)
DIV22_05980
(1)
DNQ45_23945
(1)
DNX30_02560
(1)
DS732_05485
(1)
DTL43_06215
(1)
DU321_03385
(1)
E2863_00111
(1)
E4K51_06060
(1)
E5H86_09785
(1)
E6D34_01260
(1)
EAI46_10075
(1)
ECs0120
(1)
EIA08_06050
(1)
EIZ93_07465
(1)
EN85_002000
(1)
EPS76_20815
(1)
EPS97_00795
(1)
EWK56_14625
(1)
EXX87_03070
(1)
ExPECSC038_04042
(1)
F7F11_02345
(1)
F7N46_12880
(1)
F9461_05080
(1)
F9B07_03785
(1)
FGAF848_50510
(1)
FIJ20_10985
(1)
 
More...
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 52
Entries 1 to 10 of 52
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Cryo-EM structure of Mtb Lpd bound to inhibitor complex with 2-((2-cyano-N,5-dimethyl-1H-indole)-7-sulfonamido)-N-(4-(oxetan-3-yl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-7-yl)acetamide
Kochanczyk T, Arango N, Lima CD
Not published
Assembly composition: protein only structure
Bound ligands: FAD    FAD    OU6    OU6   
Assembly name: Dihydrolipoyl dehydrogenase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161554 (Preferred)   search this ID
PDBe-KB: P9WHH9   
Electron Microscopy
2.17Å resolution
Released: 25 May 2022
Model geometry
Fit model/data
Data not analysed
8ct4
8ct4
8ct4
Co-crystal structure of optimized analog TDI-13537 provided new insights into the potency determinants of the sulfonamide inhibitor series
Dementiev AA, Michino M, Vendome J, Ginn J, Bryk R, Olland A
ACS Bio Med Chem Au (2023) [PMID: 38144256  ]
Assembly composition: protein only structure
Bound ligands: FAD    FAD    GOL    U4I    U4I   
Assembly name: Dihydrolipoyl dehydrogenase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161554 (Preferred)   search this ID
PDBe-KB: P9WHH9   
X-ray diffraction
1.69Å resolution
Released: 3 Jan 2024
Model geometry
Fit model/data
8u0q
8u0q
8u0q
1.72 Angstrom Resolution Crystal Structure of 2-Oxoglutarate Dehydrogenase Complex Subunit Dihydrolipoamide Dehydrogenase from Bordetella pertussis in Complex with FAD
Minasov G, Wawrzak Z, Skarina T, McChesney C, Grimshaw S, Savchenko A, Anderson WF, Center for Structural Genomics of Infectious Diseases (CSGID)
To be published
Assembly composition: protein only structure
Bound ligands: FAD    CA    FAD    CA   
Assembly name: Dihydrolipoyl dehydrogenase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-182092 (Preferred)   search this ID
PDBe-KB: Q7VZ16   
X-ray diffraction
1.72Å resolution
Released: 23 Aug 2017
Model geometry
Fit model/data
6aon
6aon
6aon
Structure of Mtb Lpd bound to SL827
Lima CD
Biochemistry (2013) [PMID: 24251446  ]
Assembly composition: protein only structure
Bound ligands: FAD    FAD    M52    M52   
Assembly name: Dihydrolipoyl dehydrogenase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161554 (Preferred)   search this ID
PDBe-KB: P9WHH9   
X-ray diffraction
2.4Å resolution
Released: 27 Nov 2013
Model geometry
Fit model/data
4m52
4m52
4m52
Crystal structure of a dihydrolipoamide dehydrogenase from Sinorhizobium meliloti 1021
Kumaran D, Chamala S, Evans B, Foti R, Gizzi A, Hillerich B, Kar A, LaFleur J, Seidel R, Villigas G, Zencheck W, Almo SC, Swaminathan S, New York Structural Genomics Research Consortium (NYSGRC)
To be published
Assembly composition: protein only structure
Bound ligands: FAD    FAD    SO4    EDO   
Modified residues: MSE    MSE   
Assembly name: Dihydrolipoyl dehydrogenase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-187877 (Preferred)   search this ID
PDBe-KB: Q92LK0   
X-ray diffraction
1.9Å resolution
Released: 14 Dec 2011
Model geometry
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3urh
3urh
3urh
2.5 Angstrom Resolution Crystal Structure of Dihydrolipoyl Dehydrogenase from Pseudomonas putida in Complex with FAD.
Minasov G, Wawrzak Z, Shuvalova L, Kiryukhina O, Dubrovska I, Grimshaw S, Kwon K, Anderson WF, Center for Structural Genomics of Infectious Diseases (CSGID)
To be published
Assembly composition: protein only structure
Bound ligands: FAD    FAD    GOL    TRS    TRS   
Assembly name: Dihydrolipoyl dehydrogenase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183459 (Preferred)   search this ID
PDBe-KB: Q88FB1   
X-ray diffraction
2.5Å resolution
Released: 9 Nov 2016
Model geometry
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5tr3
5tr3
5tr3
Crystal structure of the D444V disease-causing mutant of the human dihydrolipoamide dehydrogenase
Szabo E, Mizsei R, Zambo Z, Torocsik B, Weiss MS, Adam-Vizi V, Ambrus A
Free Radic Biol Med (2018) [PMID: 29908278  ]
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: FAD    FAD    GOL    PO4   
Assembly name: Dihydrolipoyl dehydrogenase, mitochondrial (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140717 (Preferred)   search this ID
PDBe-KB: P09622    P09622   
X-ray diffraction
1.84Å resolution
Released: 15 Nov 2017
Model geometry
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5j5z
5j5z
5j5z
Crystal structure of the R460G disease-causing mutant of the human dihydrolipoamide dehydrogenase.
Ambrus A, Szabo E, Weichsel A, Bui D, Wilk P, Torocsik B, Weiss MS, Montfort WR, Jordan F, Adam-Vizi V
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: FAD    FAD    SO4    TRS    TRS   
Assembly name: Dihydrolipoyl dehydrogenase, mitochondrial (Preferred)   search this complex
PDBe complex ID: PDB-CPX-140717 (Preferred)   search this ID
PDBe-KB: P09622    P09622   
X-ray diffraction
1.76Å resolution
Released: 4 Sep 2019
Model geometry
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6hg8
6hg8
6hg8
1.83 Angstrom Resolution Crystal Structure of Dihydrolipoyl Dehydrogenase from Pseudomonas putida in Complex with FAD and Adenosine-5'-monophosphate.
Minasov G, Shuvalova L, Kiryukhina O, Dubrovska I, Grimshaw S, Kwon K, Anderson WF, Satchell KJF, Joachimiak A, Center for Structural Genomics of Infectious Diseases (CSGID)
To be published
Assembly composition: protein only structure
Bound ligands: FAD    AMP    FAD    AMP    SO4   
Assembly name: Dihydrolipoyl dehydrogenase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-183459 (Preferred)   search this ID
PDBe-KB: Q88FB1   
X-ray diffraction
1.83Å resolution
Released: 4 Oct 2017
Model geometry
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6awa
6awa
6awa
Dihydrolipoamide dehydrogenase (LpdG) from Pseudomonas aeruginosa
Glasser NR, Wang BX, Hoy JA, Newman DK
J Biol Chem (2017) [PMID: 28174304  ]
Assembly composition: protein only structure
Bound ligands: FAD    FAD    DMS    DMS   
Assembly name: Dihydrolipoyl dehydrogenase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-191332 (Preferred)   search this ID
PDBe-KB: Q9I3D1   
X-ray diffraction
1.35Å resolution
Released: 15 Feb 2017
Model geometry
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5u8u
5u8u
5u8u
...
Entries 1 to 10 of 52
Entries 1 to 10 of 52