Entry status  (1)

REL

(61)

Experimental methods  (1)

X-ray diffraction

(61)

Authors  (188)

Dann III CE

(23)

Gangjee A

(23)

Hou Z

(23)

Matherly LH

(23)

Dann CE

(22)

Wilson IA

(20)

Boger DL

(16)

Deis SM

(12)

Wallace-Povirk A

(12)

O'Connor C

(11)

Wong-Roushar J

(11)

Desharnais J

(10)

Zhang Y

(10)

Benkovic SJ

(8)

Dann 3rd CE

(8)

Doshi A

(8)

Greasley SE

(8)

Katinas JM

(8)

Bao X

(7)

Kim S

(7)

Li J

(7)

Tong N

(7)

Fifer AN

(4)

Kushner J

(4)

Magdum T

(4)

Nayeen MJ

(4)

Nyman MC

(4)

O'Connor CE

(4)

Polin L

(4)

Raghavan S

(4)

Schneider M

(4)

Shah K

(4)

Shah Y

(4)

White K

(4)

Wilson MR

(4)

Wong JE

(4)

Yamashita MM

(4)

Baba S

(3)

Beardsley GP

(3)

Cai H

(3)

Caperelli CA

(3)

Connelly S

(3)

DeMartino JK

(3)

DeMartino K

(3)

Demartino JK

(3)

Ebihara A

(3)

Fujiwara S

(3)

Fukai Y

(3)

Garcia GE

(3)

George C

(3)

Kanagawa M

(3)

Kawai G

(3)

Kawai H

(3)

Kuramitsu S

(3)

Kusano M

(3)

Mitchell-Ryan S

(3)

Mitsui S

(3)

Nakagawa N

(3)

Orr S

(3)

RIKEN Structural Genomics/Proteomics Initiative (RSGI)

(3)

Sampei G

(3)

Shimasaki T

(3)

Suzuki S

(3)

Taka H

(3)

Terao K

(3)

Wallace A

(3)

Wang L

(3)

Yanagida Y

(3)

Yang S

(3)

Yokoyama S

(3)

Zhou X

(3)

Almassy RJ

(2)

Anderson WF

(2)

Arrowsmith CH

(2)

Baker EN

(2)

Berglund H

(2)

Busam R

(2)

Caradoc-Davies TT

(2)

Center for Structural Genomics of Infectious Diseases (CSGID)

(2)

Chen P

(2)

Collins R

(2)

Dahlgren LG

(2)

Dahms TE

(2)

Dickson JM

(2)

Flodin S

(2)

Flores A

(2)

Giroux EL

(2)

Graslund S

(2)

Grossmann JG

(2)

Hallberg BM

(2)

Hammarstrom M

(2)

Herman MD

(2)

Holmberg-Schiavone L

(2)

Hostomska Z

(2)

Janson CA

(2)

Jennings PA

(2)

Joachimiak A

(2)

Johansson I

(2)

Kallas A

(2)

Kan C-C

(2)

 

More...

Homo / hetero assembly  (1)

homo

(61)

Assembly composition  (1)

protein structure

(61)

Assembly polymer count  (2)

monomer

(46)

dimer

(15)

Resolution distribution

1.0 - 1.5

(3)

1.5 - 2

(22)

2.0 - 2.5

(30)

2.5 - 3

(6)

Release year distribution

1990 - 1995

(4)

1995 - 2000

(5)

2000 - 2005

(14)

2005 - 2010

(14)

2010 - 2015

(13)

2015 - 2020

(15)

2020 - 2025

(11)

Journal  (11)

Biochemistry

(20)

To be published

(11)

J Med Chem

(8)

J Mol Biol

(6)

ACS Pharmacol Transl Sci

(4)

Bioorg. Med. Chem.

(3)

J Biochem

(3)

Nucleic Acids Res

(2)

Proc Natl Acad Sci U S A

(2)

Arch Biochem Biophys

(1)

Proteins

(1)

Organism superkingdom  (2)

Eukaryota

(40)

Bacteria

(21)

Organism name  (13)

Homo sapiens

(40)

Escherichia coli

(9)

Mycobacterium tuberculosis

(2)

Alkalihalobacillus halodurans C-125

(1)

Anaplasma phagocytophilum str. HZ

(1)

Aquifex aeolicus

(1)

Brucella melitensis bv. 1 str. 16M

(1)

Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

(1)

Coxiella burnetii

(1)

Geobacillus kaustophilus HTA426

(1)

Pseudomonas aeruginosa PAO1

(1)

Streptococcus pneumoniae TIGR4

(1)

Symbiobacterium toebii

(1)

Molecule name  (16)

5'-phosphoribosylglycinamide transformylase

(60)

GAR transformylase

(60)

GART

(60)

Phosphoribosylglycinamide formyltransferase

(60)

AIR synthase

(40)

AIRS

(40)

GARS

(40)

Glycinamide ribonucleotide synthetase

(40)

Phosphoribosyl-aminoimidazole synthetase

(40)

Phosphoribosylamine--glycine ligase

(40)

Phosphoribosylformylglycinamidine cyclo-ligase

(40)

Phosphoribosylglycinamide synthetase

(40)

Trifunctional purine biosynthetic protein adenosine-3

(40)

Glycinamide ribonucleotide transformylase 1

(1)

Pyoverdine synthetase F

(1)

phosphoribosylglycinamide formyltransferase 1

(1)

Molecule type  (1)

Protein

(61)

Gene names  (17)

GART

(40)

PGFT

(40)

PRGS

(40)

purN

(20)

JW2485

(9)

b2500

(9)

Rv0956

(2)

APH_0230

(1)

BMEI1241

(1)

CBU_1737

(1)

Cj0187c

(1)

GK0266

(1)

PA2396

(1)

PurN

(1)

SP_0048

(1)

aq_857

(1)

pvdF

(1)

Interacting ligands  (51)

GAR : GLYCINAMIDE RIBONUCLEOTIDE

(28)

PO4 : PHOSPHATE ION

(13)

SO4 : SULFATE ION

(9)

GOL : GLYCEROL

(7)

CL : CHLORIDE ION

(5)

KEU : N-{4-[(1R)-4-[(2R,4R,5S)-2,4-DIAMINO-6-OXOHEXAHYDROPYRIMIDIN-5-YL]-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXYETHYL)BUTYL]BENZOYL}-D-GLUTAMIC ACID

(3)

KT5 : N-{4-4-(2,4-DIAMINO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-5-YL)-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXY-ETHYL)-BUT-2-YL-BENZOYL}-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GLUTAMIC ACID

(3)

MG : MAGNESIUM ION

(2)

NA : SODIUM ION

(2)

XSO : N-{5-[4-(2-amino-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]-3-fluoropyridine-2-carbonyl}-L-glutamic acid

(2)

138 : N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE

(1)

3Y9 : N-{4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic acid

(1)

3YA : N-{4-[4-(2-amino-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic acid

(1)

3YB : N-({4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid

(1)

3YC : (S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)butyl]thiophene-3-carbonyl}amino)pentanedioic acid

(1)

3YD : (S)-2-(7-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)heptanamido)pentanedioic acid

(1)

3YE : (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid

(1)

3YF : (S)-2-({4-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-2-carbonyl}-amino)-pentanedioic acid

(1)

3YG : (S)-2-({5-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-3-carbonyl}-amino)-pentanedioic acid

(1)

4DW : N-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid

(1)

83A : N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid

(1)

ATP : ADENOSINE-5'-TRIPHOSPHATE

(1)

BME : BETA-MERCAPTOETHANOL

(1)

CIT : CITRIC ACID

(1)

CO : COBALT (II) ION

(1)

DQB : 4-[(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)METHYL]AMINO}BENZOYL)AMINO]BUTANOIC ACID

(1)

DXY : N-({4-[(1S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-(methylsulfanyl)butyl]phenyl}carbonyl)-L-glutamic acid

(1)

DXZ : N-({4-[(1R)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-(methylsulfanyl)butyl]phenyl}carbonyl)-L-glutamic acid

(1)

DZF : 5-DEAZAFOLIC ACID

(1)

FGD : N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino}benzene-1-carbonyl)-D-glutamic acid

(1)

G71 : N-({5-[4-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid

(1)

G94 : N-({5-[3-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophen-2-yl}carbonyl)-L-glutamic acid

(1)

GRF : 5-O-phosphono-beta-D-ribofuranosylamine

(1)

IOD : IODIDE ION

(1)

KT3 : N-{4-4-(2,4-DIAMINO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-5-YL)-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXY-ETHYL)-BUT-2-YL-BENZOYL}-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GLUTAMIC ACID

(1)

NHE : 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID

(1)

NHR : 2-{4-[2-(2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL)-1-CARBOXY-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID

(1)

NHS : 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID

(1)

NO3 : NITRATE ION

(1)

PEG : DI(HYDROXYETHYL)ETHER

(1)

THH : N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID

(1)

U89 : N-[4-[[3-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-4-PYRIMIDINYL)-PROPYL]-[2-((2-OXO-2-((4-PHOSPHORIBOXY)-BUTYL)-AMINO)-ETHYL)-THIO-ACETYL]-AMINO]BENZOYL]-1-GLUTAMIC ACID

(1)

V97 : N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]thiophene-2-carbonyl}-L-glutamic acid

(1)

V9A : N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]furan-2-carbonyl}-L-glutamic acid

(1)

V9V : N-(5-{3-[(1S,7R,8R,9S)-4-amino-2-oxo-7lambda~4~-thia-3,5-diazatetracyclo[4.3.0.0~1,7~.0~7,9~]nona-3,5-dien-8-yl]propyl}thiophene-2-carbonyl)-L-glutamic acid

(1)

XRR : N-{4-[3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl}-L-glutamic acid

(1)

XSI : N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]pyridine-2-carbonyl}-L-glutamic acid

(1)

Y6U : N-{4-[3-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)propyl]benzoyl}-L-glutamic acid

(1)

Y72 : N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-3-fluorothiophene-2-carbonyl}-L-glutamic acid

(1)

Y79 : N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-glutamic acid

(1)

Y7L : N-{5-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]thiophene-2-carbonyl}-L-glutamic acid

(1)

EC number / name  (3)

2.1.2.2 : Phosphoribosylglycinamide formyltransferase 1

(61)

6.3.3.1 : Phosphoribosylformylglycinamidine cyclo-ligase

(40)

6.3.4.13 : Phosphoribosylamine--glycine ligase

(40)

Biological function  (10)

phosphoribosylglycinamide formyltransferase activity

(59)

transferase activity

(21)

catalytic activity

(14)

metal ion binding

(3)

magnesium ion binding

(2)

protein binding

(2)

ATP binding

(1)

formyl-CoA transferase activity

(1)

phosphoribosylamine-glycine ligase activity

(1)

phosphoribosylformylglycinamidine cyclo-ligase activity

(1)

Biological process  (8)

'de novo' IMP biosynthetic process

(60)

biosynthetic process

(59)

purine nucleotide biosynthetic process

(21)

DNA damage response

(9)

purine ribonucleotide biosynthetic process

(9)

tetrahydrofolate metabolic process

(2)

purine nucleobase biosynthetic process

(1)

pyoverdine biosynthetic process

(1)

Biological cell component  (2)

cytoplasm

(21)

cytosol

(20)

Compound cofactor class  (1)

Tetrahydrofolic acid

(1)

SCOP fold  (1)

Formyltransferase

(21)

SCOP family  (1)

Formyltransferase

(21)

CATH class  (1)

Alpha Beta

(49)

CATH topology  (6)

Rossmann fold

(48)

60s Ribosomal Protein L30; Chain: A;

(1)

D-amino Acid Aminotransferase; Chain A, domain 1

(1)

Dna Ligase; domain 1

(1)

Glycinamide Ribonucleotide Synthetase; Chain A, domain 4

(1)

Phosphoribosyl-aminoimidazole Synthetase; Chain A, domain 2

(1)

Pfam accession / name  (6)

PF00551 : Formyl_trans_N

(58)

PF00586 : AIRS

(1)

PF01071 : GARS_A

(1)

PF02769 : AIRS_C

(1)

PF02843 : GARS_C

(1)

PF02844 : GARS_N

(1)

Diffraction protocol  (2)

Single wavelength

(52)

MAD

(3)

Diffraction radiation source type  (2)

Synchrotron

(55)

Rotating anode

(4)

Diffraction source  (20)

ALS BEAMLINE 4.2.2

(22)

SSRL BEAMLINE BL11-1

(7)

SSRL BEAMLINE BL9-2

(5)

SSRL BEAMLINE BL9-1

(4)

APS BEAMLINE 19-ID

(2)

CHESS BEAMLINE F2

(2)

RIGAKU RU200

(2)

SPRING-8 BEAMLINE BL26B1

(2)

SSRL BEAMLINE BL7-1

(2)

ALS BEAMLINE 5.0.2

(1)

APS BEAMLINE 24-ID-E

(1)

BESSY BEAMLINE 14.1

(1)

CLSI BEAMLINE 08ID-1

(1)

ESRF BEAMLINE ID14-2

(1)

NSLS BEAMLINE X29A

(1)

NSLS BEAMLINE X4C

(1)

RIGAKU FR-E+ SUPERBRIGHT

(1)

RIGAKU RU300

(1)

SPRING-8 BEAMLINE BL26B2

(1)

SSRL BEAMLINE BL12-2

(1)

Representative Structures

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