Entry status  (1)

REL

(27)

Experimental methods  (1)

X-ray diffraction

(27)

Authors  (91)

Bach TJ

(5)

Chye ML

(5)

Miziorko HM

(5)

Blankenfeldt W

(4)

Bock T

(4)

Ferrer JL

(4)

Gerwick L

(4)

Gerwick WH

(4)

Kasten J

(4)

Maloney FP

(4)

Muller R

(4)

Müller R

(4)

Nagegowda DA

(4)

Noel JP

(4)

Pojer F

(4)

Richard SB

(4)

Sherman DH

(4)

Smith JL

(4)

Campobasso N

(3)

Harrison DH

(3)

Harrison DHT

(3)

Misra I

(3)

Rodwell VW

(3)

Saadat D

(3)

Stauffacher CV

(3)

Steussy CN

(3)

Sutherlin A

(3)

Theisen MJ

(3)

Barta ML

(2)

Burgner II JW

(2)

Burgner JW

(2)

Edwards A

(2)

Engilberge S

(2)

Erb TJ

(2)

Geisbrecht BV

(2)

Girard E

(2)

Liu X

(2)

Liu YH

(2)

Maury O

(2)

McWhorter WJ

(2)

Oppermann U

(2)

Ramyar KX

(2)

Riobe F

(2)

Riobé F

(2)

Shafqat N

(2)

Shima S

(2)

Skaff DA

(2)

Turnbull A

(2)

Vartia AA

(2)

Voegeli B

(2)

Vogeli B

(2)

Vögeli B

(2)

Wagner T

(2)

Yue WW

(2)

Zschocke J

(2)

von Delft F

(2)

Arrowsmith C

(1)

Arrowsmith CH

(1)

Bountra C

(1)

Bunkoczi G

(1)

Burgess N

(1)

Chan WL

(1)

Cooper C

(1)

Debreczeni J

(1)

Erb JT

(1)

Fu TM

(1)

Gorrec F

(1)

Hao Q

(1)

Hu M

(1)

Knight JT

(1)

Kong GK

(1)

Kong GKW

(1)

Liao P

(1)

Lo C

(1)

Lung SC

(1)

Murray JW

(1)

Niesen FH

(1)

Pike ACW

(1)

Robison AD

(1)

Roos AK

(1)

Salah E

(1)

Savitsky P

(1)

Structural Genomics Consortium (SGC)

(1)

Su X-D

(1)

Su XD

(1)

Sundstrom M

(1)

Sutherlin AL

(1)

Tetrick AM

(1)

Umeano C

(1)

Weigelt J

(1)

Wikstrom M

(1)

Homo / hetero assembly  (2)

homo

(20)

hetero

(7)

Assembly composition  (2)

protein structure

(20)

protein/protein complex

(7)

Assembly polymer count  (3)

dimer

(21)

monomer

(4)

dodecamer

(2)

Resolution distribution

1.0 - 1.5

(4)

1.5 - 2

(11)

2.0 - 2.5

(7)

2.5 - 3

(5)

Release year distribution

2000 - 2005

(5)

2005 - 2010

(9)

2010 - 2015

(4)

2015 - 2020

(10)

2020 - 2025

(1)

Journal  (6)

Proc Natl Acad Sci U S A

(13)

Biochemistry

(5)

Chembiochem

(4)

J Mol Biol

(2)

To be published

(2)

Plant Cell Physiol

(1)

Organism superkingdom  (3)

Bacteria

(18)

Eukaryota

(7)

Archaea

(2)

Organism name  (9)

Brassica juncea

(5)

Enterococcus faecalis

(5)

Moorena producens 3L

(4)

Myxococcus xanthus DK 1622

(4)

Staphylococcus aureus

(3)

Homo sapiens

(2)

Methanothermococcus thermolithotrophicus

(2)

Streptococcus mutans

(1)

Streptococcus mutans UA159

(1)

Molecule name  (9)

Hydroxymethylglutaryl-CoA synthase

(22)

HMG-CoA synthase

(14)

3-hydroxy-3-methylglutaryl coenzyme A synthase

(12)

HMGCS

(7)

CurD

(4)

3-hydroxy-3-methylglutaryl CoA synthase

(3)

Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain-containing protein

(2)

Hydroxymethylglutaryl-CoA synthase, cytoplasmic

(1)

Hydroxymethylglutaryl-CoA synthase, mitochondrial

(1)

Molecule type  (1)

Protein

(27)

Gene names  (8)

mvaS

(12)

HMGS1

(5)

LYNGBM3L_74540

(4)

MXAN_4267

(4)

SMU_943c

(2)

HMGCS

(1)

HMGCS1

(1)

HMGCS2

(1)

Interacting Molecules  (5)

Carrier domain-containing protein

(3)

Acetyl-CoA acetyltransferase

(2)

DUF35 domain-containing scaffold protein

(2)

3-hydroxy-3-methylglutaryl CoA synthase

(1)

Hydroxymethylglutaryl-CoA synthase

(1)

Interacting ligands  (18)

SO4 : SULFATE ION

(12)

GOL : GLYCEROL

(9)

COA : COENZYME A

(6)

HMG : 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A

(5)

CAA : ACETOACETYL-COENZYME A

(4)

ACO : ACETYL COENZYME *A

(2)

F24 : (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid

(2)

K : POTASSIUM ION

(2)

NA : SODIUM ION

(2)

PNS : 4'-PHOSPHOPANTETHEINE

(2)

6VG : ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] ethanethioate

(1)

A3P : ADENOSINE-3'-5'-DIPHOSPHATE

(1)

AAE : ACETOACETIC ACID

(1)

BTB : 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL

(1)

CL : CHLORIDE ION

(1)

MES : 2-(N-MORPHOLINO)-ETHANESULFONIC ACID

(1)

NO3 : NITRATE ION

(1)

TRS : 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL

(1)

EC number / name  (1)

2.3.3.10 : Hydroxymethylglutaryl-CoA synthase

(27)

Biological function  (5)

hydroxymethylglutaryl-CoA synthase activity

(27)

acyltransferase activity

(26)

transferase activity

(23)

identical protein binding

(6)

acetyl-CoA C-acetyltransferase activity

(2)

Biological process  (42)

acetyl-CoA metabolic process

(27)

farnesyl diphosphate biosynthetic process, mevalonate pathway

(27)

isoprenoid biosynthetic process

(14)

lipid metabolic process

(6)

steroid biosynthetic process

(6)

steroid metabolic process

(6)

sterol biosynthetic process

(6)

isopentenyl diphosphate biosynthetic process, mevalonate pathway

(2)

adipose tissue development

(1)

cellular response to amino acid stimulus

(1)

cellular response to fatty acid

(1)

cellular response to glucocorticoid stimulus

(1)

cellular response to hormone stimulus

(1)

cellular response to insulin stimulus

(1)

cellular response to lipopolysaccharide

(1)

cholesterol biosynthetic process

(1)

cholesterol metabolic process

(1)

ketone body biosynthetic process

(1)

kidney development

(1)

liver development

(1)

lung development

(1)

midgut development

(1)

multicellular organismal response to stress

(1)

response to bacterium

(1)

response to cAMP

(1)

response to ethanol

(1)

response to fatty acid

(1)

response to glucagon

(1)

response to glucocorticoid

(1)

response to growth hormone

(1)

response to insulin

(1)

response to linoleic acid

(1)

response to metal ion

(1)

response to monosaccharide

(1)

response to nutrient

(1)

response to peptide hormone

(1)

response to prostaglandin F

(1)

response to starvation

(1)

response to temperature stimulus

(1)

response to testosterone

(1)

response to triglyceride

(1)

response to xenobiotic stimulus

(1)

Compound cofactor class  (1)

Coenzyme A

(15)

SCOP fold  (1)

Thiolase-like

(3)

Representative Structures

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